INT-767 - CAS 1000403-03-1
Catalog number: 1000403-03-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C25H43NaO6S
Molecular Weight:
494.66
COA:
Inquire
Targets:
FXR | GPCR19
Description:
INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was just planed a Phase II trial for Hepatic fibrosis. IC50: 30 nM(EC50, FXR), 630 nM(EC50, TGR5).
Purity:
98%
Appearance:
Powder
Synonyms:
INT-767; INT 767; INT767; CS-5007; CS 5007; CS5007; HY-12434; HY 12434; HY12434; Sulfuric acid sodium 3alpha,7alpha-dihydroxy-6alpha-ethyl-24-nor-5beta-cholane-23-yl ester salt
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
INT-767 has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
TXIWHUPIUUZFFK-PMWRKVJASA-M
InChI:
InChI=1S/C25H44O6S.Na/c1-5-17-21-14-16(26)8-11-25(21,4)20-9-12-24(3)18(6-7-19(24)22(20)23(17)27)15(2)10-13-31-32(28,29)30;/h15-23,26-27H,5-14H2,1-4H3,(H,28,29,30);/q;+1/p-1/t15-,16-,17-,18-,19+,20+,21+,22+,23-,24-,25-;/m1./s1
Canonical SMILES:
CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCOS(=O)(=O)[O-])C)C)O.[Na+]
Current Developer:
Intercept Pharmaceuticals
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CAS 1000403-03-1 INT-767

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