INT-767 - CAS 1000403-03-1
Catalog number: 1000403-03-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C25H43NaO6S
Molecular Weight:
494.66
COA:
Inquire
Targets:
FXR | GPCR19
Description:
INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was just planed a Phase II trial for Hepatic fibrosis. IC50: 30 nM(EC50, FXR), 630 nM(EC50, TGR5).
Purity:
98%
Appearance:
Powder
Synonyms:
INT-767; CS-5007; HY-12434; Sulfuric acid sodium 3alpha,7alpha-dihydroxy-6alpha-ethyl-24-nor-5beta-cholane-23-yl ester salt
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
INT-767 has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
TXIWHUPIUUZFFK-PMWRKVJASA-M
InChI:
InChI=1S/C25H44O6S.Na/c1-5-17-21-14-16(26)8-11-25(21,4)20-9-12-24(3)18(6-7-19(24)22(20)23(17)27)15(2)10-13-31-32(28,29)30;/h15-23,26-27H,5-14H2,1-4H3,(H,28,29,30);/q;+1/p-1/t15-,16-,17-,18-,19+,20+,21+,22+,23-,24-,25-;/m1./s1
Canonical SMILES:
CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCOS(=O)(=O)[O-])C)C)O.[Na+]
Current Developer:
Intercept Pharmaceuticals
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related FXR Products


CAS 278779-30-9 GW4064

GW4064
(CAS: 278779-30-9)

GW4064 is a selective non-steroidal agonist of farnesoid X receptor (FXR) with EC50 value of 15 nM.

CAS 1172089-00-7 M 1145

M 1145
(CAS: 1172089-00-7)

M 1145 is a selective and potent galanin receptor 2 (GAL2) agonist with Ki value of 6.55 nM and EC50 value of 38 nM. It has an additive effect on the signal tra...

CAS 1197300-24-5 TGR5

TGR5
(CAS: 1197300-24-5)

A potent TGR5(GPCR19) agonist that showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).

CAS 1383816-29-2 Tropifexor

Tropifexor
(CAS: 1383816-29-2)

Tropifexor is a novel highly potent agonist of farnesoid X receptor (FXR), which regulates bile acid metabolism and signaling. FXR activated by Tropifexor can i...

CAS 908844-75-7 M871

M871
(CAS: 908844-75-7)

M871 is a selective galanin GAL2 receptor antagonist with Ki values of 420 and 13.1 nM for GAL1 and GAL2 receptors respectively. It blocks the pro-nociceptive e...

CAS 1000403-03-1 INT-767

INT-767
(CAS: 1000403-03-1)

INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was j...

DY-268
(CAS: 1609564-75-1)

DY-268, a pyrazol carboamide derivative, has been found to be a FXR antagonist that could be significant in studies of the biological activities of FXR. IC50: 7...

CAS 629664-81-9 Turofexorate Isopropyl

Turofexorate Isopropyl
(CAS: 629664-81-9)

Turofexorate Isopropyl is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist.

CAS 39025-23-5 Z-Guggulsterone

Z-Guggulsterone
(CAS: 39025-23-5)

Z-Guggulsterone is a broad spectrum steroid receptor ligand that acts as a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki = 37, 224 ...

CAS 1000403-03-1 INT-767

INT-767
(CAS: 1000403-03-1)

INT-767, a steride compound, has been found to be a inhibitor of FXR and TGF5 and could have probable effect against some liver and metabolic diseases. It was j...

CAS 1198085-23-2 PX 20350

PX 20350
(CAS: 1198085-23-2)

PX 20350 is a farnesoid X receptor (FXR) agonist with enhanced affinity and efficacy (12 nM and 109% (compared to GW 4064)) in FXR FRET assay and full length FX...

PX 102
(CAS: 1268245-19-7)

PX102 is a Farnesoid X-activated Receptor (FXR) agonist originated by Phenex Pharmaceuticals. PX102 demonstrated potent plasma cholesterol-lowering activity tha...

CAS 860790-38-1 M617

M617
(CAS: 860790-38-1)

M617 is a chimeric peptide that acts as a selective galanin GAL1 receptor agonist with Ki values of 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively. I...

CAS 1612191-86-2 BAR502

BAR502
(CAS: 1612191-86-2)

BAR502 is a dual FXR and GPBAR1 agonist (IC50= 2 μM and 0.4 μM for FXR and GPBAR1, respectively).

CAS 1199796-29-6 INT-777

INT-777
(CAS: 1199796-29-6)

INT-777(S-EMCA) is a novel potent and selective TGR5 agonist with remarkable in vivo activity (EC50=0.82 uM).

CAS 574013-66-4 Fexaramine

Fexaramine
(CAS: 574013-66-4)

Fexaramine is a small molecule farnesoid X receptor agonist with 100-fold increased affinity relative to natural compounds.

EP-024297

EP-024297 is a novel agonist of farnesoid X receptor (FXR). Study in Chinese hamster ovary cells showed that it is 20000-fold more potent than obeticholic acid ...

CAS 474-25-9 Chenodeoxycholic Acid

Chenodeoxycholic Acid
(CAS: 474-25-9)

Chenodeoxycholic Acid is a naturally occurring human bile acid.Chenodeoxycholic acid has been used as medical therapy to dissolve gallstones.

CAS 447410-57-3 SB756050

SB756050
(CAS: 447410-57-3)

SB756050 is a selective TGR5 agonist currently undergone testing in a phase 1 clinical trials study in the treatment of type 2 diabetes.

PX-102
(CAS: 1268244-85-4)

PX-102, also known as PX-20606, is a farnesoid X-activated receptor (FXR) agonist. PX-102 is indicated to be active in lowering plasma cholesterol, and ameliora...

Chemical Structure

CAS 1000403-03-1 INT-767

Quick Inquiry

Verification code

Featured Items