|Description||Ingenol Mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. It is effective for field treatment of actinic keratoses, significantly reduced head and non-head actinic keratosis lesions.|
|Synonyms||Ingenol 3-angelate; Picato; PEP005|
Prostratin is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). I...
Bryostatin 1, a structurally unique macrolactone marine natural product, is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Bry...
CRT0066854 is a selective and ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM for full-length PKCζ, PKCι, respectively)....
Ingenol Mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. It is effective for field treatment of actinic kera...
Pseudo RACK1 is an activator of protein kinase C which is a family of protein kinase enzymes involved in controlling the function of other proteins through the ...
[Ala107]-MBP (104-118) is a non-competitive inhibitor of PKC with IC50 value of 46-145 mM. It is a synthetic peptide analog of bovine myelin basic protein (MBP)...
LY 333531 mesylate
LY 333531 mesylate is an orally-available protein kinase C β (PKC-β) specific inhibitor used for the treatment of diabetic nephropathy and diabetic macular edem...
Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-m...
[Ala113]-MBP (104-118) is a non-competitive inhibitor of PKC with IC50 value of 46-145 mM. It is a synthetic peptide analog of bovine myelin basic protein (MBP)...
Ro 32-0432 hydrochloride
Ro 32-0432 hydrochloride is a selective and orally active inhibitor of PKC displaying a 10-fold greater selectivity for PKC-&alpha (IC50 = 9.3 nM); and a 4-fold...
H-7 dihydrochloride is a protein kinase inhibitor (IC50 = 6.0, 5.8, 3.0 and 97.0 μM for inhibition of PKC, PKG, PKA and myosin light chain kinase, respectively)...
Melittin is a polypeptide isolated from the venom of the honey bee (Apis mellifera). It inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, ...
Bisindolylmaleimide II is a potent and ATP-competitive inhibitor of protein kinase C (PKC) (IC50 = 0.01 μM). It also displays an antagonistic effect on nicotini...
CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics rela...
NSC305787 hydrochloride is a small molecule inhibitor of PKC (IC50=8.3 μM) that directly inhibits ezrin protein as an approach to prevent tumor metastasis.
(±)-Palmitoylcarnitine chloride, a long-chain acylcarnitine with both intracellular and extracellular roles, has a wide range of biological actions including th...
PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies. Ki: 14.9 nM.
SC-9 is a potent activator of protein kinase C in the presence of Ca2+.
FR 236924 is a selective PKCε activator with > 7-fold selectivity over other PKC isozymes. FR 236924 promotes glutamate release via presynaptic α7 nicotinic rec...
GO 6976, also known as PD-406976, is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. Gö 6976 blocked neurotrophin-induced signaling and ...