Indomethacin - CAS 53-86-1
Catalog number: 53-86-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H16ClNO4
Molecular Weight:
357.79
COA:
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Targets:
Cox-2 | COX
Description:
A nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively
Brife Description:
A nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively
Appearance:
Off-White Solid
Synonyms:
1-​(4-​chlorobenzoyl)​-​5-​methoxy-​2-​methyl-1H-​indole-​3-​acetic acid
Storage:
3 years -20°C powder;6 months-80°C in solvent
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Melting Point:
159-161°C
InChIKey:
CGIGDMFJXJATDK-UHFFFAOYSA-N
InChI:
1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
Canonical SMILES:
CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
1.Psychological stress exacerbates NSAID-induced small bowel injury by inducing changes in intestinal microbiota and permeability via glucocorticoid receptor signaling.
Yoshikawa K1,2, Kurihara C3, Furuhashi H3, Takajo T3, Maruta K3, Yasutake Y3, Sato H3, Narimatsu K3, Okada Y3, Higashiyama M3, Watanabe C3, Komoto S4, Tomita K3, Nagao S4, Miura S5, Tajiri H6, Hokari R3. J Gastroenterol. 2016 Apr 13. [Epub ahead of print]
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are popular painkillers, but they have serious side effects, not only in the upper gastrointestinal tract but also in the small intestine. It is well known that psychological stress may exacerbate various gastrointestinal diseases. The aim of this study was to determine whether psychological stress exacerbates NSAID enteropathy and to determine the possible underlying mechanisms for this.
2.Simultaneous determination of cucurbitacin IIa and cucurbitacin IIb of Hemsleya amabilis by HPLC-MS/MS and their pharmacokinetic study in normal and indomethacin-induced rats.
Wang S1, Guan X1, Zhong X2, Yang Z1, Huang W1, Jia B1, Cui T1. Biomed Chromatogr. 2016 Apr 8. doi: 10.1002/bmc.3733. [Epub ahead of print]
A selective and sensitive HPLC-MS/MS method was developed for the simultaneous determination of cucurbitacin IIa (cuIIa) and cucurbitacin IIb (cuIIb), the major bioactive cucurbitacins of Hemsleya amabilis, in rat plasma using euphadienol as internal standard (IS). After liquid-liquid extraction with dichloromethane, separation was achieved on a Syncronis HPLC C18 column (150 mm × 4.6 mm, 5 µm) using an isocratic mobile phase system consisting of acetonitrile-water (85:15, v/v) at a flow rate of 0.6 mL/min with a split ratio of 1:2. Detection was performed on a TSQ QUANTUM ULTRA mass spectrometer equipped with an positive-ion electrospray ionization source. The lower limits of quantification (LLOQs) were 0.25 and 0.15 ng/mL for cuIIa and cuIIb, respectively. The intra- and inter-day precision was less than 11.5% for the LLOQs and each QC level of the analytes, and accuracy was between -9.1% and 7.6%. The extraction recoveries of the analytes and IS from rat plasma were all more than 87.
3.[Effect of radiotherapy and indomethacin together in the prevention of recurrence of ectopic ossification around the elbow after resection].
Liu XH1, Jiang XY1, Gong MQ1, Zha YJ1. Beijing Da Xue Xue Bao. 2016 Apr 18;48(2):230-3.
OBJECTIVE: To discuss the effect of single low dose local radiotherapy and indomethacin together in the prevention of recurrence of ectopic ossification around the elbow after resection.
4.Deficiency of sex hormones does not affect 17-ß-estradiol-induced coronary vasodilation in the isolated rat heart.
Santos RL1, Lima JT1, Rouver WN1, Moysés MR1. Braz J Med Biol Res. 2016;49(5):e5058. doi: 10.1590/1414-431X20165058. Epub 2016 Apr 12.
The relaxation of coronary arteries by estrogens in the coronary vascular beds of naive and hypertensive rats has been well described. However, little is known about this action in gonadectomized rats. We investigated the effect of 17-ß-estradiol (E2) in coronary arteries from gonadectomized rats, as well as the contributions of endothelium-derived factors and potassium channels. Eight-week-old female and male Wistar rats weighing 220-300 g were divided into sham-operated and gonadectomized groups (n=9-12 animals per group). The baseline coronary perfusion pressure (CPP) was determined, and the vasoactive effects of 10 μM E2 were assessed by bolus administration before and after endothelium denudation or by perfusion with NG-nitro-L-arginine methyl ester (L-NAME), indomethacin, clotrimazole, L-NAME plus indomethacin, L-NAME plus clotrimazole or tetraethylammonium (TEA). The CPP differed significantly between the female and sham-operated male animals.
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Chemical Structure

CAS 53-86-1 Indomethacin

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