|Targets||CDK | NF-κB|
|Description||Indole-3-carbinol is an inhibitor of cell growth via suppressing incorporation of [3H]thymidine, triggering G1 cell cycle arrest and downregulation of cyclin-dependent kinase 6 (CDK6) expression. It exhibits anticancer activity by inhibition of NF-κB and Akt signaling pathways.
Nutritional supplement in health care products.
|Synonyms||3-Indolemethanol; (1H-Indol-3-yl)methanol; Indole-3-methanol; 1H-indol-3-ylmethanol|
|Application||Ingredient of health care products.|
3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a ribonucleotide reductase inhibitor and iron chelator with anti-tumor activity.
PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.
QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.
Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases ...
Seliciclib is an orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Selicicl...
Eupatilin, isolated from the leaves of Artemisia argyi Levl.et Vant, inhibits the signalling of MAPK, IKK, NF-κB and eotaxin-1 in bronchial epithelial cells, le...
SNOG is an amino acid nitric oxide donor that acts as a smooth muscle relaxant and platelet aggregation inhibitor. It also inhibits NF-κB activation, endothelia...
Senexin A is a selective Cell division protein kinase 8 (CDK8) inhibitor with IC50 value of 280 nM. Senexin A can bind to cdk19 in an ATP-competitive manner and...