Indantadol - CAS 202844-10-8
Catalog number:
202844-10-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H14N2O
Molecular Weight:
190.246
COA:
Inquire
Targets:
Monoamine Oxidase | NMDA Receptor
Description:
Indantadol is a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
2-(2,3-dihydro-1H-inden-2-ylamino)acetamide; CHF-3381; CNP-3381; GT-3381; V-3381; CMP-3381; N-(2-indanyl)glycinamide; N-(2-indanyl)glycinamide hydrochloride
MSDS:
Inquire
InChIKey:
MNLULKBKWKTZPE-UHFFFAOYSA-N
InChI:
1S/C11H14N2O/c12-11(14)7-13-10-5-8-3-1-2-4-9(8)6-10/h1-4,10,13H,5-7H2,(H2,12,14)
Canonical SMILES:
C1C(CC2=CC=CC=C21)NCC(=O)N
1.Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
Mattia C1, Coluzzi F. IDrugs. 2007 Sep;10(9):636-44.
Indantadol is an oral and nonselective monoamine oxidase inhibitor and NMDA antagonist that is being developed by Vernalis plc, under license from Chiesi Farmaceutici SpA, for the potential treatment of neuropathic pain. In preclinical studies, indantadol exhibited neuroprotective effects after kainite-induced seizures, and displayed anticonvulsant and antihyperalgesic activity. Indantadol also caused a dose-dependent decrease in exploratory motility. In a human heat-capsaicin-induced pain model, indantadol at a dose of 500 mg effectively reduced the area of secondary hyperalgesia to 67%. Indantadol undergoes extensive liver metabolism, withthe formation of two major metabolites - CHF-3567 and 2-aminoindane. The drug is excreted in urine partially as the parent compound, but mostly as CHF-3567. The tolerability profile of indantadol at single doses up to 600 mg and twice-daily doses up to 400 mg in clinical trials was significantly more favorable than for other NMDA antagonists.
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CAS 202844-10-8 Indantadol

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