Indacaterol Maleate - CAS 753498-25-8
Catalog number:
753498-25-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H28N2O3·C4H4O4
Molecular Weight:
508.56
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36.
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Purity:
>98%
MSDS:
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1.Indacaterol/glycopyrronium bromide fixed-dose combination for the treatment of COPD.
Schachter EN1. Drugs Today (Barc). 2013 Jul;49(7):437-46. doi: 10.1358/dot.2013.49.7.1980496.
Chronic obstructive pulmonary disease (COPD) is a worldwide problem causing prolonged and progressive morbidity as well as premature mortality. Pharmacologic treatment consists primarily in the relief of symptoms and preventing or minimizing the consequences of exacerbations. Central to the pharmacologic management of COPD is the use of bronchodilator therapy. Two major classes of agents are frequently used: β-adrenoceptor agonists and antimuscarinic agents. These drugs are used mainly in the inhalational form, primarily as rescue medication, but occasionally for maintenance in combination therapy. The availability of "ultra-long"-acting β-adrenoceptor agonists and long-acting antimuscarinic agents opens the way for combinations of these agents to be used in maintenance therapy. Such a combination offers the potential of enhanced efficacy due to additive effects and better compliance as the result of once-daily treatment. This article reviews the rationale for current bronchodilator therapy of COPD as well as the current status of a fixed-dose combined inhaler using two novel long-acting agents: glycopyrronium bromide and indacaterol maleate.
2.Effect of once-daily indacaterol maleate/mometasone furoate on exacerbation risk in adolescent and adult asthma: a double-blind randomised controlled trial.
Beasley RW1, Donohue JF2, Mehta R3, Nelson HS4, Clay M5, Moton A6, Kim HJ6, Hederer BM7. BMJ Open. 2015 Feb 3;5(2):e006131. doi: 10.1136/bmjopen-2014-006131.
OBJECTIVE: To investigate the safety and efficacy of QMF149, a once-daily, fixed-dose combination of the long-acting β2-agonist (LABA) indacaterol maleate and inhaled corticosteroid (ICS) mometasone furoate (MF) for the treatment of persistent asthma. The hypothesis was that QMF149 would not increase the risk of serious asthma exacerbations.
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CAS 753498-25-8 Indacaterol Maleate

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