INCB3344 - CAS 1262238-11-8
Catalog number:
1262238-11-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H34F3N3O6
Molecular Weight:
577.59
COA:
Inquire
Targets:
CCR
Description:
A novel, potent and selective small molecule antagonist of the mouse CCR2 receptor
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Brife Description:
A novel, potent and selective small molecule antagonist of the mouse CCR2 receptor
Appearance:
White solid
Synonyms:
N-[2-[[(3S,4S)-1-[4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxypyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide; INCB 3344; INCB-3344
Solubility:
10 mM in DMSO
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
MZEOSVPWMSEFPW-XYCDVDSTSA-N
InChI:
1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21-,22-,25-,28-/m0/s1
Canonical SMILES:
CCOC1CN(CC1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)C3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O
1.Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344.
Xie P1, Kamei M, Suzuki M, Matsumura N, Nishida K, Sakimoto S, Sakaguchi H, Nishida K. PLoS One. 2011;6(12):e28933. doi: 10.1371/journal.pone.0028933. Epub 2011 Dec 19.
PURPOSE: To investigate the effect of an intravitreally administered CCR2 antagonist, INCB3344, on a mouse model of choroidal neovascularization (CNV).
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Chemical Structure

CAS 1262238-11-8 INCB3344

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