|Description||IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.|
TWS119 is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.
CHIR 99021 is a potent glycogen synthase kinase GSK-3 inhibitor.
MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kina...
AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Al...
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold ...
SB415286 is a potent GSK3α inhibitor with IC50 and Ki values of 78 nM and 31 nM,respectively.
Indirubin-3'-monoxime, a chemical derivative of indirubin, is an inhibitor of GSK-3β with dual affinity for CDK1/5 receptor. It significantly inhibited the prol...
CHIR99021, also known as CT99021, is a GSK-3α/β inhibitor (IC50= 10 nM/6.7 nM) with antiproliferative activity in vitro and in vivo. CHIR-99021 has also been sh...
CHIR-98023 is a glycogen synthase kinase 3 inhibitor developed for the treatment of Type 2 diabetes mellitus.
SB-216763 is a glycogen synthase kinase-3 (GSK3) inhibitor, can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous ...
TCS 184 is a scrambled control peptide for use with TCS 183.
TCS 183 is a fragment 1-13 of human and mouse GSK-3β sequence. TCS 183 is potentially used as a competitive inhibitor of GSK-3β (Ser9) phosphorylation.
TC-G 24 is a potent and brain penetrating GSK-3β inhibitor (IC50 = 17 nM) with selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). TC-G 24 has been show...
A cyclin-dependent kinases and glycogen synthase kinase-3 inhibitor with IC50 values of 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
GSK-3 inhibitor 1
GSK-3 inhibitor 1 is a potent GSK-3 inhibitor.
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis...
AZD 2858 hydrochloride
The hydrochloride salt form of AZD 2858. AZD 2858 is a potent and selective Glycogen Synthase Kinase-3β (GSK-3β; Ki = 4.9 nM) inhibitor used for Alzheimer’s dis...
CHIR-98014 is a selective GSK3 inhibitor with IC50s of 0.65 nM and 0.58 nM for GSK-3α and GSK-3β; potentiate insulin activation of glucose transport and utiliza...
TDZD-8 is a derivative of thiadiazolidine (TDZD) and acts as a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β)....
Tideglusib is a potent, selective and irreversible small molecule non-ATP-competitive GSK3 inhibitor that has been investigated as a potential treatment for Alz...