|Description||IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.|
TC-G 24 is a potent and brain penetrating GSK-3β inhibitor (IC50 = 17 nM) with selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). TC-G 24 has been show...
AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Al...
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold ...
CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with...
CHIR99021, also known as CT99021, is a GSK-3α/β inhibitor (IC50= 10 nM/6.7 nM) with antiproliferative activity in vitro and in vivo. CHIR-99021 has also been sh...
TCS 184 is a scrambled control peptide for use with TCS 183.
A cyclin-dependent kinases and glycogen synthase kinase-3 inhibitor with IC50 values of 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
Bikinin is an ATP-competitive Arabidopsis GSK-3 inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.
TWS 119 is a glycogen synthase kinase-3β (GSK-3) inhibitor (IC50 = 30 nM). TWS 119 induces neuronal differentiation in pluripotent murine embryonal carcinoma ce...
MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kina...
CHIR-98014 is a selective GSK3 inhibitor with IC50s of 0.65 nM and 0.58 nM for GSK-3α and GSK-3β; potentiate insulin activation of glucose transport and utiliza...
GSK-3 inhibitor 1
GSK-3 inhibitor 1 is a potent GSK-3 inhibitor.
CP21R7, a selective GSK-3β inhibitor, which could probably influence luciferase activity at some extent.
A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such ...
SB-216763 is a glycogen synthase kinase-3 (GSK3) inhibitor, can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous ...
TCS 2002 is a potent and cell-permeable inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration of TCS 2002 inhibits cold water stress-induced tau hyperphosphory...
TCS 183 is a fragment 1-13 of human and mouse GSK-3β sequence. TCS 183 is potentially used as a competitive inhibitor of GSK-3β (Ser9) phosphorylation.
2B-(SP) is a selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3).
SB415286 is a potent GSK3α inhibitor with IC50 and Ki values of 78 nM and 31 nM,respectively.