IM-12 - CAS 1129669-05-1
Catalog number: 1129669-05-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H20FN3O2
Molecular Weight:
377.41
COA:
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Targets:
GSK-3
Description:
IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.
Purity:
>98%
Synonyms:
N/A
MSDS:
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InChIKey:
ZKJAZFUFPPSFCO-UHFFFAOYSA-N
InChI:
InChI=1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
Canonical SMILES:
CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F
1.Extra-large-pore zeolites with two-dimensional channels formed by 14 and 12 rings.
Paillaud JL;Harbuzaru B;Patarin J;Bats N Science. 2004 May 14;304(5673):990-2.
Stable zeolites that have larger pore apertures and a three-dimensional pore topology are of interest because they could be used to adsorb larger molecules, particularly for application in oil refining. Several large-pore zeolitic materials with channels formed by openings of more than 12 rings are known, but all of them have a one-dimensional channel system that limits their use in catalysis. We report the synthesis and some characterizations of IM-12, a thermally stable germanium-containing zeolite that contains the first two-dimensional channel system with extra-large pores formed by 14- and 12-ring channels.
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CAS 1129669-05-1 IM-12

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