ILK-IN-1 - CAS 1333146-24-9
Catalog number: 1333146-24-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H30F3N5O
Molecular Weight:
533.59
COA:
Inquire
Targets:
Integrin
Description:
ILK-IN-1, a ILK inhibitor, has been found to restrain the tumor cell growth through regulating signaling pathways related to oncogenesis and tumor progression. IC50: 0.6 μM.
Purity:
98%
Appearance:
Powder
Synonyms:
ILK-IN-1; CHEMBL1830587; GTPL8116; SCHEMBL8536228; BDBM50353484; CS-4936
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
ILK-IN-1 is a ILK inhibitor that has been found to restrain the tumor cell growth through regulating signaling pathways related to oncogenesis and tumor progression.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
GHBUPSVATJKTRR-UHFFFAOYSA-N
InChI:
InChI=1S/C30H30F3N5O/c1-34-29(39)15-10-25-20-28(38(36-25)27-13-11-26(12-14-27)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-9,11-14,20,35H,10,15-19H2,1H3,(H,34,39)
Canonical SMILES:
CNC(=O)CCC1=NN(C(=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)N5CCNCC5
1.Novel target to kill CLL.
Robak T;Smolewski P Blood. 2015 Jan 8;125(2):211-2. doi: 10.1182/blood-2014-10-606582.
In this issue of Blood, Liu et al report on OSU-T315, a new agent that specifically disrupts the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway and shows high proapoptotic activity against chronic lymphocytic leukemia (CLL) cells, which may indicate a potential therapeutic application in this disease.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Integrin Products


CAS 904763-27-5 ATN-161 trifluoroacetate salt

ATN-161 trifluoroacetate salt
(CAS: 904763-27-5)

ATN-161 trifluoroacetate salt is a beta integrin antagonist with antitumor activity. It is a five -amino-acid peptide derived from the synergy region of fibrone...

CAS 327613-57-0 BIO 5192

BIO 5192
(CAS: 327613-57-0)

BIO 5192 is a selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM) wth selectivity for α4β1 over a range of other integrins...

R-BC154

R-BC154, a high affinity fluorescent α4β1/α9β1 integrin antagonist (Kd= 12.7 and 38 nM, respectively), was based on a series of N-phenylsulfonyl proline dipepti...

CAS 317353-73-4 TCS 2314

TCS 2314
(CAS: 317353-73-4)

TCS 2314 is an integrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM) that inhibits the activation of inflammatory cells.

CAS 187735-94-0 BIO 1211

BIO 1211
(CAS: 187735-94-0)

BIO 1211 is a selective and high affinity integrin α4β1 (Very Late Antigen 4; VLA-4) inhibitor with 200-fold selectivity for the activated form of α4β1 (KD = 70...

CAS 154303-05-6 Echistatin, α1 isoform

Echistatin, α1 isoform
(CAS: 154303-05-6)

Echistatin, α1 isoform is a potent and irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). It exhibits inhibitory activity for bone reabsorption (IC50 = 0.1 n...

CAS 848644-86-0 P11

P11
(CAS: 848644-86-0)

P11 is a potent antagonist of the integrin αvβ3-vitronectin interaction with IC50 value of 25.72 nM.

Obtustatin

Obtustatin is an integrin α1β1 inhibitor with IC50 value of 0.8 nM for α1β1 binding to type IV collagen. Some research shows that it has antitumor efficacy in a...

ILK-IN-1
(CAS: 1333146-24-9)

ILK-IN-1, a ILK inhibitor, has been found to restrain the tumor cell growth through regulating signaling pathways related to oncogenesis and tumor progression. ...

Vedolizumab
(CAS: 943609-66-3)

Vedolizumab is a monoclonal antibody developed by Millennium Pharmaceuticals for the treatment of ulcerative colitis and Crohn's disease under the trade name En...

CAS 150915-40-5 Tirofiban hydrochloride monohydrate

Tirofiban hydrochloride monohydrate
(CAS: 150915-40-5)

Tirofiban is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Tirofiban is an antithrombotic used in the treatment of unstable angina...

CAS 180144-61-0 SR121566A

SR121566A
(CAS: 180144-61-0)

SR121566A, a non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, has been shown to block platelet aggregation induced by a wide variety of agonists incl...

CAS 1307293-62-4 ALG1001

ALG1001
(CAS: 1307293-62-4)

ALG1001, also known as Luminate, a first-in-class integrin peptide therapy, is an angiogenesis inhibitors and Integrin alpha 5 beta 1 modulator. A study from Jo...

CAS 916734-43-5 TC-I 15

TC-I 15
(CAS: 916734-43-5)

TC-I 15 is a potent α2β1 integrin inhibitor (IC50 = 12 and 715 nM for the inhibition of human platelet adhesion to type I collagen and for platelets under stati...

CAS 232271-19-1 TR-14035

TR-14035
(CAS: 232271-19-1)

TR14035 blocked the binding of human alpha(4)beta(7) to an (125)I-MAdCAM-Ig fusion protein with IC(50) values of 0.75 nM. TR14035 blocked binding of human alpha...

CAS 455264-31-0 Zaurategrast

Zaurategrast
(CAS: 455264-31-0)

Zaurategrast is an oral α4-integrin inhibitor. It significantly decreased the capacity of lymphocytes to bind vascular adhesion molecule-1 (VCAM-1) and the expr...

CAS 262438-43-7 ATN-161

ATN-161
(CAS: 262438-43-7)

ATN-161 is a small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for i...

CAS 1259028-99-3 BTT 3033

BTT 3033
(CAS: 1259028-99-3)

BTT 3033 is a selective inhibitor of α2β1 integrin (EC50 = 130 nM for α2β1 binding to collagen I) that binds to the α2I domain. BTT 3033 inhibits platelet aggre...

CAS 344897-95-6 Leukadherin-1

Leukadherin-1
(CAS: 344897-95-6)

Leukadherin-1, also known as LA1, is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1. Leukadherin-1 suppresses hu...

CAS 162112-37-0 RWJ 50271

RWJ 50271
(CAS: 162112-37-0)

RWJ 50271 is a selective inhibitor of LFA-1/ICAM-1 mediated cell adhesion (sICAM) (IC50= 5 μM in HL60 cells).

Quick Inquiry

Verification code

Featured Items