II-B08 - CAS 1143579-78-5
Catalog number: 1143579-78-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C33H27N5O4
Molecular Weight:
557.61
COA:
Inquire
Targets:
PTPN11
Description:
This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC50 is 5.5 µM. II-B08 may be therapeutically useful for anticancer and antileukemia treatment in the future.
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Purity:
98%
Appearance:
powder
Synonyms:
3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid,CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX.
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
anticancer and antileukemia treatment
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams.
Boiling Point:
No Data Available
Melting Point:
No Data Available
InChIKey:
RATFAFAWIWHLMR-UHFFFAOYSA-N
InChI:
InChI=1S/C33H27N5O4/c1-37-28-19-29(39)26(33(41)42)18-25(28)31(32(37)23-10-6-3-7-11-23)27-20-38(36-35-27)17-16-30(40)34-24-14-12-22(13-15-24)21-8-4-2-5-9-21/h2-15,18-20,39H,16-17H2,1H3,(H,34,40)(H,41,42)
Canonical SMILES:
CN1C2=CC(=C(C=C2C(=C1C3=CC=CC=C3)C4=CN(N=N4)CCC(=O)NC5=CC=C(C=C5)C6=CC=CC=C6)C(=O)O)O
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II-B08
(CAS: 1143579-78-5)

This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC5...

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