(+)-Igmesine hydrochloride - CAS 130152-35-1
Catalog number:
130152-35-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H30ClN
Molecular Weight:
355.94
COA:
Inquire
Targets:
Opioid Receptor
Description:
Igmesine is a selective σ1 receptor ligand (KD = 19.1 nM), with nearly no activity at σ2 receptors (IC50 > 1000 nM). It was developed by Pfizer. Igmesine inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner and IC50 value is approximately 100 nM. Igmesine can weekly inhibit brain 5-HT uptake in vitro. It exhibits neuroprotective and antidepressant effects. No developments were reported for the treatment of Cognition disorders, Diarrhoea and Major depressive disorder.
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Purity:
98%
Appearance:
White solid
Synonyms:
Igmesine HCl; CI-1019; JO-1784;(+)-(E)-N-(Cyclopropylmethyl)-alpha-ethyl-N-methyl-alpha-(3-phenyl-2-propenyl)benzenemethanamine hydrochloride
Solubility:
Soluble to 50 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Cognition disorders; Diarrhoea; Major depressive disorder
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
SCHQQPAJNUHKSV-RSGUCCNWSA-N
InChI:
1S/C23H29N.ClH/c1-3-23(22-14-8-5-9-15-22,24(2)19-21-16-17-21)18-10-13-20-11-6-4-7-12-20;/h4-15,21H,3,16-19H2,1-2H3;1H/b13-10+;
Canonical SMILES:
C1(C[N@@]([C@@](c2ccccc2)(C\C=C\c2ccccc2)CC)C)CC1.Cl
Current Developer:
Jouveinal; Pfizer
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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