IG-105 - CAS 905978-63-4
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Not Intended for Therapeutic Use. For research use only.
IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has good safety in mice. IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon, and pancreas with IC(50) values between 0.012 and 0.298 mumol/L. It was also active in drug-resistant tumor cells and not a P-glycoprotein substrate. It inhibited microtubule assembly followed by M-phase arrest, Bcl-2 inactivation, and then apoptosis through caspase pathways.
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white solid powder
IG-105; IG105; IG 105
Current Developer:
Chinese Academy of Medical Sciences and Peking Union Medical College
1.Enhancing medical compliance of patients with convulsive epilepsy in rural community: a randomized intervention trial.
Li J1, Si Y, Hu J, Liu L, Deng Y, He J, Zhang NM, Zhou D. Epilepsia. 2013 Nov;54(11):1988-96. doi: 10.1111/epi.12382. Epub 2013 Sep 30.
PURPOSE: This randomized intervention trial was to determine whether the implementation of a practical intervention was effective in enhancing medical compliance and improving seizure control among patients with convulsive epilepsy in rural communities in western China.
2.N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide as a novel tubulin ligand against human cancer.
Wang YM1, Hu LX, Liu ZM, You XF, Zhang SH, Qu JR, Li ZR, Li Y, Kong WJ, He HW, Shao RG, Zhang LR, Peng ZG, Boykin DW, Jiang JD. Clin Cancer Res. 2008 Oct 1;14(19):6218-27. doi: 10.1158/1078-0432.CCR-08-0550.
PURPOSE: We have synthesized a new tubulin ligand N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide (IG-105). This work investigates its anticancer effect and mechanism.
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CAS 905978-63-4 IG-105

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