Ifosfamide - CAS 3778-73-2
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Not Intended for Therapeutic Use. For research use only.
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DNA Alkylator/Crosslinker
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
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NSC109724, Isophosphamide
1.Carcinosarcoma of the Lesser Omentum: A Unique Case Report and Literature Review.
Wang B1, Ren KW, Yang YC, Wan DL, Li XJ, Zhai ZL, Zhang LL, Zheng SS. Medicine (Baltimore). 2016 Apr;95(14):e3246. doi: 10.1097/MD.0000000000003246.
Carcinosarcoma is a rare tumor consisting of epithelial and mesenchymal components, both of which are histologically malignant. It usually runs an aggressive clinical course, with higher metastatic potential than other kinds of carcinomas or sarcomas.Here, we present an extremely uncommon case of carcinosarcoma occurred in the lesser omental bursa in a 65-year-old Chinese man. Metastasis was observed 2 months after operation and disappeared completely after chemotherapy. Until now, 3 years after surgery, the patient is still alive without any signs or symptoms of recurrence.To our knowledge, this is the first case of carcinosarcoma originated from lesser omentum. Surgical resection and the ifosfamide-based combination chemotherapy may be effective to carcinosarcoma in the lesser omentum.
2.Acute fibrinous and organising pneumonia: a rare histopathological variant of chemotherapy-induced lung injury.
Gupta A1, Sen S2, Naina H1. BMJ Case Rep. 2016 Apr 6;2016. pii: bcr2016214721. doi: 10.1136/bcr-2016-214721.
Bleomycin-induced lung injury is the most common chemotherapy-associated lung disease, and is linked with several histopathological patterns. Acute fibrinous and organising pneumonia (AFOP) is a relatively new and rare histological pattern of diffuse lung injury. We report the first known case of bleomycin-induced AFOP. A 36-year-old man with metastatic testicular cancer received three cycles of bleomycin, etoposide and cisplatin, before being transitioned to paclitaxel, ifosfamide and cisplatin. He subsequently presented with exertional dyspnoea, cough and pleuritic chest pain. CT of the chest demonstrated bilateral ground glass opacities with peribronchovascular distribution and pulmonary function tests demonstrated a restrictive pattern of lung disease with impaired diffusion. Transbronchial biopsy revealed intra-alveolar fibrin deposits with organising pneumonia, consisting of intraluminal loose connective tissue consistent with AFOP.
3.Risk-Stratified Initial Salvage Therapy for Relapsed or Refractory Metastatic Germ Cell Tumors.
Narayan V1, Gunnarsson O1, Hwang WT2, Squillante CM1, Nathanson KL1, Stadtmauer EA1, Vaughn DJ3. Clin Genitourin Cancer. 2016 Mar 24. pii: S1558-7673(16)30069-6. doi: 10.1016/j.clgc.2016.03.015. [Epub ahead of print]
BACKGROUND: Salvage treatment with either conventional-dose chemotherapy (CDCT) or high-dose chemotherapy with autologous stem cell transplantation (HDCT) offers curative potential for patients with relapsed or refractory germ cell tumor (GCT). However, the optimal initial salvage strategy remains controversial, and the criteria for appropriate patient selection are not clear.
4.An unresectable retroperitoneal malignant fibrous histiocytoma: A case report.
Hsiao PJ1, Chen GH1, Chang YH1, Chang CH1, Chang H2, Bai LY3. Oncol Lett. 2016 Apr;11(4):2403-2407. Epub 2016 Feb 25.
Malignant fibrous histiocytoma (MFH) is most commonly observed in the extremities and the trunk but rarely in retroperitoneum. The present case report documents a 64-year-old man who was admitted with an abdominal palpable mass for 6 months. After a thorough investigation, a tumor of the retroperitoneum was identified adhered to adjacent organs and vessels. The patient experienced mild hydronephrosis and hydroureter as a result of the tumor compression. A number of previous surgeons considered the tumor unresectable and suggested palliative treatment. En bloc resection of the tumor was attempted but incomplete surgery was performed initially as the tumor was friable and prone to bleeding. Therefore, a biopsy of the tumor was performed and a double J ureteral stent was set for hydronephrosis. Histopathological examination confirmed the tumor was an MFH. The patient received neo-adjuvant chemotherapy with 4 cycles of mesna, doxorubicin, ifosfamide, and dacarbazine (MAID).
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CAS 3778-73-2 Ifosfamide

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