IDE-1 - CAS 1160927-48-9
Catalog number:
1160927-48-9
Category:
Stem Cell Molecule
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H18N2O5
Molecular Weight:
306.31
COA:
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Description:
IDE-1 was identified in a high throughput screen as an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells. IDE-1 is able to generate Sox17+/FoxA2+ cells to an equal or greater efficiency than that of protein (i.e. Activin A or Nodal) IDEs in mouse or human ES cell cultures. It functions in part via activation of TGF-β signaling, as evident by Smad2 phosphorylation. IDE-1 chemically induced endoderm can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos.
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Purity:
0.98
Appearance:
Solid powder
Synonyms:
7-[2-(2-Carboxybenzylidene)hydrazinyl]-7-oxoheptanoic acid; IDE1; IDE-1; IDE 1
MSDS:
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Application:
Differentiation
InChIKey:
ABKJCDILEUEJSH-MHWRWJLKSA-N
InChI:
1S/C15H18N2O5/c18-13(8-2-1-3-9-14(19)20)17-16-10-11-6-4-5-7-12(11)15(21)22/h4-7,10H,1-3,8-9H2,(H,17,18)(H,19,20)(H,21,22)/b16-10+
Canonical SMILES:
O=C(O)CCCCCC(N/N=C/C1=CC=CC=C1C(O)=O)=O
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CAS 1160927-48-9 IDE-1

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