Idarubicin Hydrochloride - CAS 57852-57-0
Catalog number: B0084-094874
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H27NO9.HCl
Molecular Weight:
533.95
COA:
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Targets:
Topoisomerase
Description:
Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.
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Purity:
>98%
Synonyms:
4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl
MSDS:
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1.A comparative study of idarubicin 12 mg/m(2) and 8 mg/m(2) combined with cytarabine as the first induction regimen for adult acute myeloid leukemia patients.
Zhou L1, Liu X1, Liu H1, Zhu W1, Cai X1, Song K1, Zheng C1, Tang B1, Sun Z1. Onco Targets Ther. 2016 Feb 29;9:985-91. doi: 10.2147/OTT.S96176. eCollection 2016.
OBJECTIVE: This study aimed to explore a suitable dose of idarubicin (IDA) combined with cytarabine for the initial induction regimen for acute myeloid leukemia (AML) patients.
2.Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.
Chen Y1, Sakamuru S2, Huang R2, Reese DH3, Xia M2. Toxicol In Vitro. 2016 Apr;32:287-96. doi: 10.1016/j.tiv.2016.01.011. Epub 2016 Jan 25.
In vertebrates, the retinol (vitamin A) signaling pathway (RSP) controls the biosynthesis and catabolism of all-trans retinoic acid (atRA), which regulates transcription of genes essential for embryonic development. Chemicals that interfere with the RSP to cause abnormal intracellular levels of atRA are potential developmental toxicants. To assess chemicals for the ability to interfere with retinol signaling, we have developed a cell-based RARE (Retinoic Acid Response Element) reporter gene assay to identify RSP disruptors. To validate this assay in a quantitative high-throughput screening (qHTS) platform, we screened the Library of Pharmacologically Active Compounds (LOPAC) in both agonist and antagonist modes. The screens detected known RSP agonists, demonstrating assay reliability, and also identified novel RSP agonists including kenpaullone, niclosamide, PD98059 and SU4312, and RSP antagonists including Bay 11-7085, LY294002, 3,4-Methylenedioxy-β-nitrostyrene, and topoisomerase inhibitors (camptothecin, topotecan, amsacrine hydrochloride, and idarubicin).
3.Pentoxifylline affects idarubicin binding to DNA.
Gołuński G1, Borowik A1, Lipińska A2, Romanik M1, Derewońko N2, Woziwodzka A1, Piosik J3. Bioorg Chem. 2016 Apr;65:118-25. doi: 10.1016/j.bioorg.2016.02.005. Epub 2016 Feb 20.
Anticancer drug idarubicin - derivative of doxorubicin - is commonly used in treatment of numerous cancer types. However, in contrast to doxorubicin, its biophysical properties are not well established yet. Additionally, potential direct interactions of idarubicin with other biologically active aromatic compounds, such as pentoxifylline - representative of methylxanthines - were not studied at all. Potential formation of such hetero-aggregates may result in sequestration of the anticancer drug and, in consequence, reduction of its biological activity. This work provide description of the idarubicin biophysical properties as well as assess influence of pentoxifylline on idarubicin interactions with DNA. To achieve these goals we employed spectrophotometric methods coupled with analysis with the appropriate mathematical models as well as flow cytometry and Ames test. Obtained results show influence of pentoxifylline on idarubicin binding to DNA and are well in agreement with the data previously published for other aromatic ligands.
4.Clofarabine Plus Low-Dose Cytarabine Is as Effective as and Less Toxic Than Intensive Chemotherapy in Elderly AML Patients.
Takahashi K1, Kantarjian H2, Garcia-Manero G2, Borthakur G2, Kadia T2, DiNardo C2, Jabbour E2, Pierce S2, Estrov Z2, Konopleva M2, Andreeff M2, Ravandi F2, Cortes J3. Clin Lymphoma Myeloma Leuk. 2016 Mar;16(3):163-168.e2. doi: 10.1016/j.clml.2015.11.016. Epub 2015 Nov 24.
INTRODUCTION: Most patients with acute myeloid leukemia (AML) age ≥ 60 years are not offered intensive induction because of high mortality. Phase 2 studies of clofarabine plus low-dose cytarabine (CLDA) as frontline therapy for elderly AML patients demonstrated high response and acceptable toxicity.
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CAS 57852-57-0 Idarubicin Hydrochloride

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