ID-8 - CAS 147591-46-6
Catalog number: 147591-46-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C16H14N2O4
Molecular Weight:
298.29
COA:
Inquire
Targets:
Others
Description:
ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.
Purity:
>98%
Synonyms:
ID-8; ID 8; ID8.
MSDS:
Inquire
InChIKey:
VVZNWYXIOADGSW-UHFFFAOYSA-N
InChI:
InChI=1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3
Canonical SMILES:
CC1=C(C2=C(N1C3=CC=C(C=C3)OC)C=C(C=C2)O)[N+](=O)[O-]
1.Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes.
Huyut Z;Beydemir Ş;Gülçin İ J Biochem Mol Toxicol. 2017 Sep;31(9). doi: 10.1002/jbt.21930. Epub 2017 Apr 26.
Carbonic anhydrases (CAs, E.C.4.2.1.1) play a critical role in many important physiological events and treatment of some diseases. Flavonoids or phenolic compounds have been discovered as novel CAs inhibitors instead of the traditional sulfonamides, with different binding to CAs, pro-drug activities, and new inhibition mechanisms. Here, we investigated the inhibition effects of some flavonoids including malvin, callistephin, oenin, pelargonin, silychristin, and 1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol (ID-8) against hCA I and II, which purified from human erythrocytes by affinity column chromatography. Both hCA isoenzymes were inhibited by flavonoids, with IC;50; and K;i; values in the range of 2.34 nM to 346.5 μM and 51.01-99.55 μM for hCA I and 86.60-750.00 μM for hCA II, respectively. These results showed that flavonoids especially malvin and oenin effectively inhibited hCA I and II isoenzymes. Hence, they may be used as an effective CA inhibitor in medical applications for treatment of certain diseases such as glaucoma, in the future.
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CAS 147591-46-6 ID-8

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