Icilin - CAS 36945-98-9
Catalog number:
36945-98-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H13N3O4
Molecular Weight:
311.29
COA:
Inquire
Targets:
TRP Channel
Description:
Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
Yellow-orange solid
Synonyms:
AG 3-5; 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one; 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Both heat sensitive (VR1) and cold-sensitive (CMR1 (rat); TRPM8 (human)) receptors
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Density:
1.415 g/cm3
InChIKey:
RCEFMOGVOYEGJN-UHFFFAOYSA-N
InChI:
1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
Canonical SMILES:
O=C1N([H])C(C2=CC([N+]([O-])=O)=CC=C2)=CCN1C3=CC=CC=C3O
Current Developer:
Tufts University
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related TRP Channel Products


CAS 138977-28-3 Capsazepine

Capsazepine
(CAS: 138977-28-3)

Capsazepine, a benzazepine derivative, has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses. IC50: 562 nM (Rat T...

CAS 332117-28-9 TCS 5861528

TCS 5861528
(CAS: 332117-28-9)

TCS 5861528 is a selective TRPA1 blocker with IC50 values are 14.3 and 18.7μM respectively), attenuates diabetes mellitus hypersensitivity and displays antinoci...

Pyr6
(CAS: 245747-08-4)

Pyr6, a pyrazole derivative, is a selective inhibitor of ransient receptor potential cation 3 (TRPC3) channels that inhibited Orai1- and TRPC3-mediated Ca(2+) e...

SAR7334
(CAS: 1333210-07-3)

SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC.

PF-4840154
(CAS: 1332708-14-1)

PF-4840154 has been foundd to be superior than Mustard Oil as a TrpA1 agonists. IC50: 97 nM and 23 nM (EC50) for hTrpA1 and rTrpA1 respectively.

CAS 1221443-94-2 A-1165442

A-1165442
(CAS: 1221443-94-2)

A-1165442 is a potent, competitive and orally available modality-differentiated second-generation TRPV1 antagonist with good analgesic efficacy and a temperatur...

SAR7334 hydrochloride
(CAS: 1333207-63-8)

The hydrochloride salt form of SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC.

Pyr10
(CAS: 1315323-00-2)

Pyr10, a pyrazole derivative, is a TRPC3-selective inhibitor that could be effective in the study of cellular functions. IC50: 0.72 uM and 13.08 uM for TRPC3-RO...

CAS 349085-38-7 HC-030031

HC-030031
(CAS: 349085-38-7)

HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

RQ-00203078
(CAS: 1254205-52-1)

RQ-00203078 is a potent, selective and orally active TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). RQ-00203078 bloc...

SN 2
(CAS: 823218-99-1)

SN 2 is a novel and potent small molecule activator of TRPML3. Its EC50 value is 1.13 uM. It had a similar synergistic effect and reached up-to 10-fold enhancem...

PF 05105679
(CAS: 1398583-31-7)

PF-05105679 is a selective TRPM8 Antagonist with clinical efficacy in cold-related pain. IC50 value is 103 nM. It shows >100-fold selectivity for TRPM8 over a p...

CAS 821768-06-3 JNJ-17203212

JNJ-17203212
(CAS: 821768-06-3)

JNJ-17203212 is a novel, reversible, and selective TRPV1 antagonist which could not inhibit related TRP channels. Its IC50 values are 65 nM and 102 nM for human...

CAS 472981-92-3 SB-366791

SB-366791
(CAS: 472981-92-3)

SB-366791 is a potent, and selective cinnamide TRPV1 antagonist (pA2 = 7.71 at hVR1) with IC50 of 5.7±1.2 nM.

CAS 942206-85-1 GSK1016790A

GSK1016790A
(CAS: 942206-85-1)

GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urina...

Mavatrep
(CAS: 956274-94-5)

Mavatrep is an orally bioavailable, potent and selective TRPV1 antagonist with Ki value of 6.5 nM, which exhibits minimal effect on the enzymatic activity of CY...

MK-2295
(CAS: 878811-00-8)

MK-2295 is a potent TRPV1 antagonist. TRPV1 antagonists has the potential as analgesic and anti-inflammatory agents.

CAS 68489-09-8 WS12

WS12
(CAS: 68489-09-8)

WS12 is a potent TRPM8 agonist. It acts as a cooling agent with EC50 value of 193 nM. It robustly activated TRPM8 in low micromolar concentrations, thus display...

CAS 55224-94-7 AP18

AP18
(CAS: 55224-94-7)

AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 µM at human and mouse...

AMG8562
(CAS: 1041478-78-7)

AMG8562 is a novel vanilloid receptor TRPV1 modulator.

Chemical Structure

CAS 36945-98-9 Icilin

Quick Inquiry

Verification code

Featured Items