Ibutilide Fumarate - CAS 122647-32-9
Catalog number: 122647-32-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Calcium Channel
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potentia
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1.Increasing gap junction coupling suppresses ibutilide-induced torsades de pointes.
Ruan L1, Quan X1, Li L1, Bai R2, Ni M1, Xu R1, Zhang C1. Exp Ther Med. 2014 May;7(5):1279-1284. Epub 2014 Mar 4.
Drug-induced torsades de pointes (TdP) is common with class III antiarrhythmic drugs. Increased transmural dispersion of repolarization (TDR) contributes significantly to the development of TdP. Gap junctions play an important role in maintaining TDR in long QT syndrome. The present study examined the effect of a gap junction enhancer, antiarrhythmic peptide 10 (AAP10), on ibutilide-induced TdP. Coronary-perfused rabbit ventricular wedge preparations were used to evaluate the effect of AAP10 on ibutilide-induced arrhythmia. Transmural electrocardiograms and action potentials were recorded simultaneously. Early afterdepolarizations (EADs), R-on-T extrasystole, TdP and changes in Tpeak-end (Tp-e) and the Tp-e/QT ratio were observed. Changes in the levels of non-phosphorylated connexin 43 (Cx43) were measured by immunoblotting. Compared with those in the control group, the QT interval, Tp-e/QT and incidence rates of EAD and TdP increased with augmented dephosphorylation in the ventricular wedge preparations perfused with ibutilide under conditions of hypokalemia and hypomagnesemia.
2.Investigation of the antifibrillatory drug interactions between Amiodarone and Ibutilide in isolated, perfused Rabbit hearts.
Almotrefi AA1, Bukhari IA1, Alhumayyd MS1. Fundam Clin Pharmacol. 2015 Dec;29(6):553-7. doi: 10.1111/fcp.12141. Epub 2015 Sep 10.
In view of the reliability of the serial-shock method of measuring ventricular fibrillation threshold (VFT) in quantitatively assessing the antifibrillatory potency of many anti-arrhythmic drugs and the alarming reports of the proarrhythmic effects of several anti-arrhythmic agents, it was decided to use the above technique to study the possible interactions that may occur when anti-arrhythmic drugs from different classes are combined. Hearts isolated from New Zealand white rabbits of either sex weighing 1.5-2 kg were perfused by the Langendorff method with McEwen's solution. In six hearts, measurement of VFT was made in the absence of any drug throughout the experiments. Perfusion with either amiodarone or ibutilide produced significant, dose-dependent increase in VFT. In addition, there was no significant difference in the increase in VFT produced by the combined infusion of 1 μmol of amiodarone and 0.01 μmol of ibutilide and the summation of the increases produced by the separate infusion of these two concentrations.
3.The modified stepwise ablation guided by low-dose ibutilide in chronic atrial fibrillation trial (The MAGIC-AF Study).
Singh SM1, d'Avila A2, Kim YH3, Aryana A4, Mangrum JM5, Michaud GF6, Dukkipati SR7, Barrett CD8, Heist EK9, Parides MK7, Thorpe KE10, Reddy VY11. Eur Heart J. 2016 Feb 4. pii: ehw003. [Epub ahead of print]
AIMS: Complex fractionated atrial electrograms (CFAE) are targeted during persistent atrial fibrillation (AF) ablation. However, many CFAE sites are non-specific resulting in extensive ablation. Ibutilide has been shown to reduce left atrial surface area exhibiting CFAE. We hypothesized that ibutilide administration prior to CFAE ablation would identify sites critical for persistent AF maintenance allowing for improved procedural efficacy and long-term freedom from atrial arrhythmias.
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CAS 122647-32-9 Ibutilide Fumarate

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