Ibutamoren Mesylate - CAS 159752-10-0
Catalog number:
B0084-448720
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C28H40N4O8S2
Molecular Weight:
624.77
COA:
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Targets:
GHSR
Description:
Ibutamoren, also known as MK-677 or L-163,191, is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-448720 20 mg $169 In stock
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Purity:
>98%
Synonyms:
MK-677; Crescendo; MK 0677; MK-0677; MK0677
MSDS:
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1. PROGRESS IN THE DEVELOPMENT OF NEW DRUGS IN ALZHEIMER’S DISEASE
A. PIAU, F. NOURHASHÉMI, C. HEIN, C. CAILLAUD, B. VELLAS. J Nutr Health Aging
Among other hormonal compounds, insulin-like growth factor-1 (IGF-1) is supposed to increase clearance of Abeta. Prel iminary evidence shows that the growth hormone secretagogue MK-677 (ibutamoren mesylate), a potent inducer of IGF-1 secretion, could improve cognitive function in cognitively impaired patients. However, MK-677 was ineffective at slowing the rate of progression of Alzheimer’s disease in a clinical trial. Excessive levels of corticosteroid have been associated with impaired attention, concentration and memory, and in vivo studies suggest that prolonged exposure to high circulating levels of glucocorticoid may be associated with a faster progression of AD. Mifepristone is a glucocorticoid receptor antagonist and could improve cognition in AD. Pilot trials in patients with AD provide data on the safety and the feasibility of this approach but longer studies are needed. HF0220, a 7-hydroxysteroid pathway modulator, is also under clinical evaluation (table 1).
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CAS 159752-10-0 Ibutamoren Mesylate

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