Ibuprofen piconol - CAS 64622-45-3
Catalog number: B0046-448719
Category: APIs
Molecular Formula:
C19H23NO2
Molecular Weight:
297.4
COA:
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Description:
Ibuprofen piconol is an anti-inflammatory agent that can be synthesized from Ibuprofen. It acts as a cyclooxygenase inhibitor.
Ordering Information
Catalog Number Size Price Stock Quantity
B0046-448719 5 g $288 In stock
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Synonyms:
Pimeprofen; Staderm; Vesicum; pyridin-2-ylmethyl 2-[4-(2-methylpropyl)phenyl]propanoate
MSDS:
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InChIKey:
ACEWLPOYLGNNHV-UHFFFAOYSA-N
InChI:
InChI=1S/C19H23NO2/c1-14(2)12-16-7-9-17(10-8-16)15(3)19(21)22-13-18-6-4-5-11-20-18/h4-11,14-15H,12-13H2,1-3H3
Canonical SMILES:
CC(C)CC1=CC=C(C=C1)C(C)C(=O)OCC2=CC=CC=N2
1.Ibuprofen piconol hydrolysis in vitro in plasma, whole blood, and serum using different anticoagulants.
Christensen JM1, Stalker D. J Pharm Sci. 1991 Jan;80(1):29-31.
Hydrolysis kinetics of ibuprofen piconol to ibuprofen were determined in vitro in plasma, whole blood, and serum. Varying initial concentrations of ibuprofen piconol with different anticoagulants (EDTA, heparin, citrate, or no anticoagulant) were used in determining the effects each had on the rate of ibuprofen piconol hydrolysis. Varying the initial concentration of ibuprofen piconol did not alter the hydrolysis half-life (concentration range from 50 to 200 micrograms/mL). The anticoagulant used altered the hydrolysis half-life. For plasma, the half-life was shortest when no anticoagulant was present (t 1/2 = 2.5 h) and longer with the presence of anticoagulants; for citrate, t 1/2 = 8.0 h, for heparin; t 1/2 = 15.5 h; and for EDTA, t 1/2 = 161.8 h. Red blood cell uptake of ibuprofen piconol was minimal and ranged from 0.4 to 4.1% over the ibuprofen piconol concentrations used in the study.
2.Contact dermatitis from ibuprofen piconol.
Kubo K1, Shirai K, Akaeda T, Oguchi M. Contact Dermatitis. 1988 Mar;18(3):188-9.
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