Ibuprofen (Dolgesic) - CAS 15687-27-1
Catalog number: 15687-27-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C13H18O2
Molecular Weight:
206.28
COA:
Inquire
Targets:
Cox-2 | COX
Description:
An inhibitor of COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively
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Brife Description:
An inhibitor of COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively
Appearance:
White Solid
Synonyms:
α-​methyl-​4-​(2-​methylpropyl)​-benzeneacetic acid
Solubility:
DMSO 41 mg/mL (198.75 mM); Ethanol 41 mg/mL (198.75 mM)
Storage:
3 years -20°C powder;6 months-80°C in solvent
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Melting Point:
73-76°C
InChIKey:
HEFNNWSXXWATRW-UHFFFAOYSA-N
InChI:
1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Canonical SMILES:
CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
1.Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets
T. Hummel á O. Cramer á P. Mohammadian. Eur J Clin Pharmacol (1997) 52: 107±114
Ibuprofen produced a dose-related decrease in chemosomatosensory event-related potential amplitudes 60 min after administration but the acoustical event-related potentials, the tracking performance and the ratings for ``tiredness'' were not signi®cantly a€ected by ibuprofen. In addition, there was no consistent doserelated effect on the background EEG activity. Therefore, the dose-related decrease in pain-related evoked potential amplitudes was more likely to be due to the antinociceptive properties ibuprofen than non-specific effects such as sedation.
2.Cognitive and motor function after administration of hydrocodone bitartrate plus ibuprofen, ibuprofen alone, or placebo in healthy subjects with exercise-induced muscle damage: a randomized, repeated-dose, placebo-controlled study
George J. Allen · Tamara L. Hartl · Shannon Duffany. Psychopharmacology (2003) 166:228–233
Multiple assessment strategies were included to ensure relevance of the measures to real-world activities requiring sustained attention, concentration, and coordinated movement. The hydrocodone-plus-ibuprofen combination is typically administered for short-term pain relief, usually less than 10 days. Onset of action is rapid, within approximately 16 min, and peak effect is reached in 1 h (Sunshine et al. 1997; Wideman et al. 1999). Previous studies have shown this combination to have a shorter time to onset of analgesia and greater analgesic efficacy than codeine-acetaminophen, and its analgesic efficacy has been found to be similar to that of oxycodoneacetaminophen (Sunshine et al. 1997; Wideman et al. 1999; Ziccardi et al. 1998). Duration of action appears to be longer than that of either drug. Both the dosing interval and assessment schedule were designed to represent accurately the regimen many athletes follow after soft tissue injury.
3.Comparative Pharmacology of S(+)-Ibuprofen and (RS)-Ibuprofen
A. M. Evans. Clin Rheumatol (2001) (Suppll):S9-S14
NSAIDs appear to exhibit most of their pharmacological effects by inhibition of the cyclooxygenase-mediated transformation of arachidonic acid to thromboxane and the various prostaglandins. For the profen class of NSAIDs, including ibuprofen, naproxen and ketoprofen, the S-enantiomers are effective inhibitors of cycloxygenase (COX forms 1 and 2) in vitro and elicit analgesic and anti-inflammatory effects in vivo. Because the R-enantiomers do not inhibit prostaglandin synthesis, one might expect that they would also be ineffective as analgesic and anti-inflammatory agents in vivo. Although this is true for some of the profens, ibuprofen and fenoprofen represent two notable examples in which this general rule does not hold. In both of these cases, the R-enantiomers undergoes extensive enzyme-mediated 'chiral inversion' in experimental animals- effectively, the body transforms some of the 'R-isomer' to the 'S-isomer'. Therefore, when the R(-)-isomer of ibuprofen was tested for pharmacological activity in experimental animal models, it was found to share the analgesic, antiinflammatory and antipyretic effects of S(+)-ibuprofen.
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Chemical Structure

CAS 15687-27-1 Ibuprofen (Dolgesic)

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