|Targets||Neurokinin 1 Receptor|
|Description||Ibodutant is a tachykinin receptor antagonist. It selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations. It is a candidate drug for irritable bowel syndrome diarrhea. It was developed by The Menarini Group. It is in the clinical phase III.|
|Solubility||Soluble in DMSO, not in water|
|Application||Ibodutant is a candidate drug for irritable bowel syndrome diarrhea.|
|Quality Standard||In-house standard|
|Boiling Point||921.8±65.0 °C | Condition: Press: 760 Torr|
|Melting Point||195-196 °C|
|Density||1.24±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||Ibodutant was developed by The Menarini Group. It is in the clinical phase III.|
C14TKL-1 is an endogenous human tachykinin-like peptide and a potent NK1 receptor agonist (EC50 = 1 nM).
Orvepitant is a potent and selective Neurokinin-1 (NK1) antagonist. It may be potential therapeutic for the treatment of patients with major depressive disorder...
Ibodutant is a tachykinin receptor antagonist. It selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations...
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