Ibandronic acid - CAS 114084-78-5
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Not Intended for Therapeutic Use. For research use only.
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Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
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1. Oral versus intravenous ibandronic acid: a comparison of treatment options for metastatic bone disease
Kyriaki Mystakidou, Evangelia Stathopoulou. J Cancer Res Clin Oncol (2008) 134:1303–1310
Bisphosphonates are the standard of care for treating MBD (Coleman 2001; Diel et al. 2000; Mystakidou et al. 2005), and several are used in the clinical setting (zoledronic acid, ibandronic acid, pamidronate and clodronate). Ibandronic acid is the only bisphosphonate available in both oral and intravenous (IV) formulations. Results from individual phase 3 trials suggest similar efficacy of oral and IV ibandronic acid for the prevention of SREs in women with breast cancer and MBD (Diel et al. 2000; Body et al. 2003, 2004). However, the efficacy and safety of oral and IV formulations of ibandronic acid have not been evaluated previously in a head-to-head study. The primary objective of this study was to evaluate the efficacy (clinical response) and safety of oral and IV ibandronic acid in patients with various tumour types. The secondary study objective was to determine the influence of ibandronic acid on analgesic use, metastatic bone pain, and QoL.
2. Modulating Effect of Matrices with Calcium Phosphate Coating on Cytotoxicity of Strontium Ranelate and Ibandronic Acid In Vitro
I. A. Khlusov, N. V. Ryazantseva, A. I. Vengerovskii, K. A. Nechaev. Bulletin of Experimental Biology and Medicine, Vol. 157, No. 2, June, 2014 PHARMACOLOGY AND TOXICOLOGY
Ibandronic acid (IA) increased intracellular concentration of ROS by 57% (Table 1), then cell death occurred. Metabolic mechanism of nitrogen-containing Ibandronic acid (IA) and other bisphosphonates is associated with the inhibition of farnesyl diphosphate synthase, the enzyme of mevalonate pathway of cholesterol, sterols and isoprenoid lipids synthesis. Geranyl pyrophosphate and farnesyl pyrophosphate activating regulatory proteins Ras, Rho, Rac, Rab, and Cdc42 with guanosine triphosphatase function are synthesixed via the mevalonate pathway. Rac proteins control activity of NADPH oxidase catalyzing the production of superoxide anion radical.
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CAS 114084-78-5 Ibandronic acid

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