|Description||Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).|
|Synonyms||I 2906; I-2906|
Sitafloxacin is active against methicillin-resistant staphylococci, Streptococcus pneumoniae and other streptococci with reduced susceptibility to levofloxacin ...
Kanamycin B is an aminoglycoside antibiotic.
The hydrochloride salt form of Valnemulin, a wide-spectrum antibiotic, has been found to have strong antibacterial activity especially against mycoplasma and sp...
Sarafloxacin is a quinolone antibiotic drug, inhibiting the topoisomerase II ligase domain.
Tildipirosin is a novel 16-membered-ring macrolide used in veterinary medicine. Tildipirosin treats bacterial pathogens including Mannheimia haemolytica and Pas...
Cadazolid, also referred to ACT-179811,is a new fluoroquinolone-oxazolidinone antibiotic with potent activity against Clostridium difficile.
Roxithromycin is a semi-synthetic macrolide antibiotic that inhibits bacterial cell growth and replication. It is used to treat respiratory tract, urinary and s...
Vaborbactam is a selective beta-lactamase inhibitor under the development of Rempex Pharmaceuticals. Vaborbactam is a broad-spectrum inhibitor, especially resto...
PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidr...
Gemifloxacin Mesylate，a fluoroquinolone, is an oral broad-spectrum antibacterial agent that show great in vitro activity against a wide variety of respiratory t...
Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and i...
Amodiaquine is a drug which used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. It has similar action to chloroquine. It is not a...
Bacitracin Zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
Doripenem is a broad spectrum antibiotic that is in the β-lactam subclass known as carbapenems. It inhibits the synthesis of bacterial cell walls by attaching t...
Dihydrostreptomycin sesquisulfate is a derivative of Streptomycin used to treat bacterial diseases in cattle, pigs and sheep.
Tylosin is a 16-member-ring macrolide produced through the fermentation of Streptomyces fradiae, a species of actinobacteria found in soil. It is effective agai...
Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin (IC50=1.5 μg/ml).
Ornidazole Levo-, the levo-isomer of Ornidazole, with good tolerance, and good in vivo distribution, it can be used to prepare anti-anaerobic bacteria infection...
Tilmicosin phosphate, an antibiotic, has been commonly used as a veterinary drug against ovine respiratory disease for bovine and ovine.