I2906 - CAS 331963-29-2
Catalog number:
331963-29-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H37N3O4
Molecular Weight:
443.58
COA:
Inquire
Targets:
Antibacterial
Description:
Under in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).
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Purity:
>98%
Synonyms:
I 2906; I-2906
MSDS:
Inquire
1.In vitro and in vivo activities of a new lead compound I2906 against Mycobacterium tuberculosis.
Lu J1, Yue J, Wu J, Luo R, Hu Z, Li J, Bai Y, Tang Z, Xian Q, Zhang X, Wang H. Pharmacology. 2010;85(6):365-71. doi: 10.1159/000299795. Epub 2010 Jun 8.
BACKGROUND: Due to the long duration of treatment and the emergence of multidrug-resistant strains, new antitubercular agents are urgently needed. I2906, as a novel lead, was screened and tested for efficacy in vitro and in vivo.
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CAS 331963-29-2 I2906

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