Hyperin - CAS 482-36-0
Catalog number: 482-36-0
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Chemical Family:
Hyperin isolated from the herb of Hypericum perforatum L. It maybe as a candidate therapeutic agent for the treatment of vascular inflammatory and occlusive vascular diseases, inhibiting HMGB1 signaling pathway and activating Nur77 receptor.
Yellow powder
4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-3-(beta-d-galactopyranosyloxy)-5; quercetin 3-O-β-D-galactopyranoside
neuro-protective effect; anti-inflammatory and antioxidative effects;
Quality Standard:
Enterprise Standard
1.87 g/cm3
1.Urinary Clearance of Cranberry Flavonol Glycosides in Humans.
Wang Y;Singh AP;Nelson HN;Kaiser AJ;Reker NC;Hooks TL;Wilson T;Vorsa N J Agric Food Chem. 2016 Oct 3. [Epub ahead of print]
Cranberry is reported to have health benefits including prevention of urinary tract infections and other chronic diseases, due to the high content of polyphenols including flavonols and flavan-3-ols. The aim of this study was to determine the clearance of flavonol glycosides and flavan-3-ols and/or their metabolites in human urine. Ten healthy women volunteers ingested 240 ml cranberry juice containing flavonol glycosides. Urine samples were collected at 0, 90, 225 and 360 minutes post-ingestion. While flavan-3-ols were not detected, five flavonol glycosides common in cranberry were identified. Quercetin-3-galactoside, the most abundant cranberry flavonol, exhibited highest peak urine concentration (Cmax) of 1315 pg/mg creatinine, followed by quercetin-3-rhamnoside, quercetin-3-arabinoside, myricetin-3-arabinoside and myricetin-3-galactoside. Quercetin-3-arabinoside showed delayed clearance, Cmax at 237 min (Tmax), relative to other flavonols (90-151 min). Both aglycone and conjugated sugar moiety structure mediates the flavonol's bioavailability. Inter-individual variation for bioavailability and clearance is also apparent. Metabolites, e.g. glucoronides, were not detected.
2.Polyphenolic profile in cider and antioxidant power.
Zuriarrain A;Zuriarrain J;Puertas AI;Dueñas MT;Ostra M;Berregi I J Sci Food Agric. 2015 Nov;95(14):2931-43. doi: 10.1002/jsfa.7036. Epub 2014 Dec 30.
BACKGROUND: ;The aim of this work was to find the effect of polyphenolic compounds in Basque ciders on the following parameters: antioxidant activity, browning, protein-precipitating capacity, turbidity and reduction potential. These five parameters are highly important, as they affect the taste, the visual aspect and the preservation of cider, and are mainly related to polyphenolic compounds.;RESULTS: ;Procyanidin B1 and procyanidin B2 showed a significant positive effect on antioxidant activity. p-Coumaric acid, (-)-epicatechin and hyperin had a significant positive effect on protein-precipitating capacity. Tyrosol had a significant negative effect on reduction potential.;CONCLUSION: ;Procyanidin B1 and procyanidin B2 are the most powerful antioxidants in Basque cider, while p-coumaric acid, (-)-epicatechin and hyperin are those with greatest capacity to precipitate proteins. Ciders with higher tyrosol concentration will have less reduction potential and higher antioxidant reservoir.;© 2014 Society of Chemical Industry.
3.Purification of Flavonoids from Chinese Bayberry (Morella rubra Sieb. et Zucc.) Fruit Extracts and α-Glucosidase Inhibitory Activities of Different Fractionations.
Yan S;Zhang X;Wen X;Lv Q;Xu C;Sun C;Li X Molecules. 2016 Aug 31;21(9). pii: E1148. doi: 10.3390/molecules21091148.
Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit have a diverse flavonoid composition responsible for the various medicinal activities, including anti-diabetes. In the present study, efficient simultaneous purification of four flavonoid glycosides, i.e., cyanidin-3-O-glucoside (1), myricetin-3-O-rhamnoside (2), quercetin-3-O-galactoside (3), quercetin-3-O-rhamnoside (4), from Chinese bayberry pulp was established by the combination of solid phase extract (SPE) by C18 Sep-Pak(®) cartridge column chromatography and semi-preparative HPLC (Prep-HPLC), which was followed by HPLC and LC-MS identification. The purified flavonoid glycosides, as well as different fractions of fruit extracts of six bayberry cultivars, were investigated for α-glucosidase inhibitory activities. The flavonol extracts (50% methanol elution fraction) of six cultivars showed strong α-glucosidase inhibitory activities (IC50 = 15.4-69.5 μg/mL), which were higher than that of positive control acarbose (IC50 = 383.2 μg/mL). Four purified compounds 1-4 exerted α-glucosidase inhibitory activities, with IC50 values of 1444.3 μg/mL, 418.8 μg/mL, 556.4 μg/mL, and 491.8 μg/mL, respectively. Such results may provide important evidence for the potential anti-diabetic activity of different cultivars of Chinese bayberry fruit and the possible bioactive compounds involved.
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CAS 482-36-0 Hyperin

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