Hydroxyzine pamoate - CAS 10246-75-0
Catalog number:
10246-75-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H27ClN2O2.C23H16O6
Molecular Weight:
763.28
COA:
Inquire
Targets:
Histamine Receptor
Description:
Hydroxyzine pamoate, a derivative of hydroxyzine, is a histamine H1-receptor antagonist that has been used as anxiolytic and antihistaminic so that it is probably effective in the treatment of insomnia and withdrawal treatment.
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Purity:
98%
Appearance:
Powder
Synonyms:
HYDROXYZINE PAMOATE;HYDROXYZINE PAMOATE SALT;hydroxyzine embonate;HYDROXYZINEPAMOATE,USP;1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine, pamoate;2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 2-[2-[4-[(4-chlorophe
Solubility:
10 mM in H2O
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Hydroxyzine pamoate is a histamine H1-receptor antagonist that has been used as anxiolytic and antihistaminic so that it is probably effective in the treatment of insomnia and withdrawal treatment.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Density:
1.182g/cm3
InChIKey:
ASDOKGIIKXGMNB-UHFFFAOYSA-N
InChI:
InChI=1S/C23H16O6.C21H27ClN2O2/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-10,24-25H,11H2,(H,26,27)(H,28,29);1-9,21,25H,10-17H2
Canonical SMILES:
C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
1.Efficacy of the Sequential Administration of Melatonin, Hydroxyzine, and Chloral Hydrate for Recording Sleep EEGs in Children.
Dirani M1, Nasreddine W1, Melhem J1, Arabi M2, Beydoun A3. Clin EEG Neurosci. 2016 Jan 10. pii: 1550059415621830. [Epub ahead of print]
Sedation of children for electroencephalography (EEG) recordings is often required. Chloral hydrate (CH) requires medical clearance and continuous monitoring. To try to reduce personnel and time resources associated with CH administration, a new sedation policy was formulated. This study included all children who underwent an EEG during a consecutive 3-month period following the implementation of the new sedation policy, which consists of the sequential administration of melatonin, hydroxyzine (if needed), and CH (if needed). The comparator group included all children with a recorded EEG during a consecutive 3-month period when the sedation policy consisted of the sole administration of CH. A total of 803 children with a mean age of 7.9 years (SD = 5.1, range = 0.5-17.7 years) were included. Sleep EEG recordings were obtained in 364 of 385 children (94.6%) using the old sedation policy and in 409 of 418 children (97.9%) using the new one.
2.[Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn].
Zheng L, Bing Z, Wei L, Qiang W. Zhonghua Shao Shang Za Zhi. 2015 Jun;31(3):177-80.
OBJECTIVE: To study the clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn.
3.A Case Report of Kratom Addiction and Withdrawal.
Galbis-Reig D. WMJ. 2016 Feb;115(1):49-52; quiz 53.
Kratom, a relatively unknown herb among physicians in the western world, is advertised on the Internet as an alternative to opioid analgesics, as a potential treatment for oploid withdrawal and as a "legal high" with minimal addiction potential. This report describes a case of kratom addiction in a 37-year-old woman with a severe oploid-like withdrawal syndrome that was managed successfully with symptom-triggered clonidine therapy and scheduled hydroxyzine. A review of other case reports of kratom toxicity, the herb's addiction potential, and the kratom withdrawal syndrome is discussed. Physicians in the United States should be aware of the growing availability and abuse of kratom and the herb's potential adverse health effects, with particular attention to kratom's toxicity, addictive potential, and associated withdrawal syndrome.
4.[The Current State of Inappropriate Drug Use among Elderly Assisted-Living Residents].
Hirotani Y1, Kawamura H, Nakamura M, Urashima Y, Myotoku M. Gan To Kagaku Ryoho. 2015 Dec;42 Suppl 1:43-4.
Previous studies have reported that elderly assisted-living residents use multiple drug combinations and inappropriate drugs.The aim of this study was to assess the drug use and its consequences in residents of a nursing facility.We examined the prescriptions of all residents in a nursing facility in Osaka from their medical records.Of the total 67 residents, 48 were women.The average age of the residents was 86 years, the average number of prescription drugs they took was 6.4, and the average number of diseases present was 4.9. Correlation between the number of diseases and the drugs taken was significant (p<0.05), but the correlation between the degree of independence for activities of daily living and the number of the drugs taken was not significant.The most commonly present health condition was bone fracture.About 50% of the residents used a psychotropic drug and prescription drugs such as amantadine and hydroxyzine, which are not advisable for elderly people.
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Chemical Structure

CAS 10246-75-0 Hydroxyzine pamoate

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