|Description||Hydroxyzine (sold as Vistaril, Atarax) is a first-generation antihistamine of the diphenylmethane and piperazine class.|
|Synonyms||Hydroxyzine dihydrochloride, Hydroxyzine hydrochloride, Vistaril, Atarax|
JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and ana...
GSK-189,254 is a H3 histamine receptor inverse agonist. It has subnanomolar affinity for the H3 receptor with Ki of 0.2nM. It possesses stimulant and nootropic ...
Aceprometazine is a Histamine H1 receptor antagonist as an approved drug. It can be used in combination with meprobamate for the treatment of sleep disorders su...
Bepotastine stimulates P-gp-mediated ATP hydrolysis with Km, Vmax, and Vmax/Km values of 1.25 mM, 108 nmol/min/mg protein, and 0.087 mL/min/mg protein, respecti...
ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist has been investigated as a treatment for ADHD, Alzheimer's disease, and schizophr...
Pyrilamine maleate salt
Pyrilamine maleate salt is a first generation antihistamine and binds with high affinity to G(q/11) protein. It is commonly utilized as a radioligand binding as...
Ciproxifan maleate, also called as FUB-359 maleate, is a highly potent and strongly selective histamine H3 inverse agonist/antagonist (IC50 = 9.2 nM) which disp...
Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects.
Fenspiride is an α adrenergic and H1 histamine receptor antagonist. It is an oxazolidinone spiro compound. It is used as a drug in the treatment of certain resp...
Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma...
Bilastine is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
Dimetotiazine is a histamine H1 receptor antagonist. It is a phenothiazine drug used for the treatment of migraine.
Benzquinamide hydrochloride is an antiemetic compound with antihistaminic, anticholinergic and sedative properties. The mechanism of action is not quite sure an...
The dihydrochloride salt form of Mizolastine which is effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and other allergy sy...
Azatadine is a new antihistamine acts as histamine for histamine H1- receptor inhibitor ( IC50 = 6.5 nM and 10 nM, respectively).
Dexbrompheniramine is an histamine H1-receptor antagonist used for the treatment of allergic conditions including hay fever or urticaria. It is the pharmacologi...
Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation...
Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.
GSK-239512 is a histamine H3 receptor antagonist. In Jun 2015, Phase-II for Schizophrenia in USA was discontinued. Phase II clinical trilas for the treatment of...
Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators, used as self-medication for the temporary relief of ...