|Description||Hydroxysafflor yellow A is a flavonoid derived. It is extracted from traditional Chinese medicine Carthamus tinctorius L. It possesses anti-tumor activity. It could inhibit LPS-induced VSMCs proliferation and migration, and inhibited LPS-induced upregulation of TLR-4 expression in vitro. It attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. It inhibited the proliferation of 3T3-L1 preadipocytes and cell viability greatly decreased in a dose and time dependent manner. It inhibited adipogenesis by increasing HSL promoter activities. It can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacity and inhibiting the expression of TGF-β. It prevents steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells.|
|B0084-474840||100 mg||$198||In stock|
|Synonyms||(6E)-2,5-dihydroxy-6-[(E)-1-hydroxy-3-(4-hydroxyphenyl)prop-2-enylidene]-2,4-bis[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohex-4-ene-1,3-dione;2,5-Cyclohexadien-1-one, 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-((2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl)-;SaffloMin A;HSYA|
|Solubility||DMSO: 39 mg/mL|
|Application||Hydroxysafflor yellow A could inhibit LPS-induced VSMCs proliferation and migration, and inhibited LPS-induced upregulation of TLR-4 expression in vitro. It attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. It inhibited adipogenesis by increasing HSL promoter activities. It can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacity and inhibiting the expression of TGF-β. It prevents steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||1015.8±65.0 °C | Condition: Press: 760 Torr|
|Melting Point||184-186 °C|
|Density||1.851±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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