|Description||Hydroxysafflor yellow A is a flavonoid derived. It is extracted from traditional Chinese medicine Carthamus tinctorius L. It possesses anti-tumor activity. It could inhibit LPS-induced VSMCs proliferation and migration, and inhibited LPS-induced upregulation of TLR-4 expression in vitro. It attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. It inhibited the proliferation of 3T3-L1 preadipocytes and cell viability greatly decreased in a dose and time dependent manner. It inhibited adipogenesis by increasing HSL promoter activities. It can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacity and inhibiting the expression of TGF-β. It prevents steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells.|
|B0084-474840||100 mg||$198||In stock|
|Synonyms||(6E)-2,5-dihydroxy-6-[(E)-1-hydroxy-3-(4-hydroxyphenyl)prop-2-enylidene]-2,4-bis[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohex-4-ene-1,3-dione;2,5-Cyclohexadien-1-one, 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-((2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl)-;SaffloMin A;HSYA|
|Solubility||DMSO: 39 mg/mL|
|Application||Hydroxysafflor yellow A could inhibit LPS-induced VSMCs proliferation and migration, and inhibited LPS-induced upregulation of TLR-4 expression in vitro. It attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. It inhibited adipogenesis by increasing HSL promoter activities. It can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacity and inhibiting the expression of TGF-β. It prevents steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Boiling Point||1015.8±65.0 °C | Condition: Press: 760 Torr|
|Melting Point||184-186 °C|
|Density||1.851±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
Flutroline is a γ-carboline antipsychotic agent. It is safe and efficient.
Gly-Phe-Arg, a superpotent synthetic tripeptide, mimics the mud-crab pumping pheromone.
triptophenolide is isolated from ethyl acetate extracts of the roots of Tripterygium wilfordii Hook. f. In vitro, it can remarkably inhibit the delayed type hyp...
GC376 is a 3CLpro inhibitor which is previously reported to be active against the 3CLpro of multiple coronaviruses, including SARS-CoV, but with highest potency...
BFCAs-1 is a polyamino polycarboxylic bifunctional chelating agent, which has a broad range of applications in chemistry, biology and medicine and diagnostic im...
Galangin is a flavonoid naturally found in herbs acts as an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
Alendronate sodium hydrate
Alendronate, a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.
PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor.
Tinyatoxin is a neurotoxin, acting via vanilloid receptors of sensory nerves.
FMK 9a is a covalent autophagin-1 inhibitor (IC50= 80 and 73 μM in FRET and LRA assay).
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.
Aspartame is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages.
CP-432 is an EP4 prostaglandin agonist , potential useful for the treatment of glaucoma and ocular hypertension.
NIH-12848 is putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor (IC50= 1 μM) but did not inhibit the α and β PI5P4K isoforms at concentrat...
Trodusquemine, also called as MSI-1436 or Aminosterol-1436, with the potential to treat type 2 diabetes and obesity, it is a non-competitive cholestane inihbito...
Carbazochrome sodium sulfonate (AC-17)
Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids.
Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (H...
ML329 is a small molecule MITF inhibitor that inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks t...
GLPG-1690, an imidazopyridine derivative, has been found to be a ENPP2 protein inhibitor that could probably be effective as an anti-inflammatory agent and is u...
Retosiban is a oxytocin receptor antagonist. It was developed by GlaxoSmithKline for the treatment of preterm labour. Retosiban has high affinity for the oxytoc...