Hydroxycitric acid - CAS 6205-14-7
Catalog number: B0005-012863
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Molecular Formula:
C6H8O8
Molecular Weight:
208.122
COA:
Certificate of Analysis-Hydroxycitric acid 6205-14-7 B17ZJ10265  
Chemical Family:
Other Natural Compounds
Description:
Hydroxycitric acid is a natural compound found in the fruits of Garcinia atroviridis. Hydroxycitric acid acts as an inhibitor of the enzyme ATP-citrate lyase.
Nutritional supplement in health care products.
Ordering Information
Catalog Number Size Price Stock Quantity
B0005-012863 500 g $198 In stock
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Purity:
60%
Synonyms:
Hydroxycitrate; (-)-Hydroxycitric acid; Hydroxycitricacid; 1,2-Dihydroxy-1,2,3-propanetricarboxylic acid
Solubility:
Soluble in DMSO
MSDS:
Inquire
Application:
Ingredient of health care products.
InChIKey:
ZMJBYMUCKBYSCP-UHFFFAOYSA-N
InChI:
InChI=1S/C6H8O8/c7-2(8)1-6(14,5(12)13)3(9)4(10)11/h3,9,14H,1H2,(H,7,8)(H,10,11)(H,12,13)
Canonical SMILES:
C(C(=O)O)C(C(C(=O)O)O)(C(=O)O)O
1.Contributions of cytosolic and mitochondrial acetyl-CoA syntheses to the activation of lipogenic acetate in rat liver.
Goldberg RP;Brunengraber H Adv Exp Med Biol. 1980;132:413-8.
Acetate derived from ethanol oxidation is activated by cytosolic and mitochondrial acetyl-CoA synthetases before contributing to the extra-mitochondrial processes of fatty acid and 3-beta-hydroxysterol synthesis. Mitochondrially-generated acetyl-CoA is transferred to the cytosol via citrate and ATP-citrate lyase; this transfer is blocked by (-)-hydroxycitrate. Rats were injected IV with 3.3 mmol/kg of [2-3H,2-14C] acetate and IP with either 0.5 mmol/kg hydroxycitrate or saline. After one hour, the rats were killed and the incorporation of label was measured in liver fatty acids and 3-beta-hydroxysterols. The 3H/14C ratio was increased by 12 and 13% in the fatty acids and 3-beta-hydroxysterols of the hydroxycitrate-treated group. The lower ratio in the fatty acids and 3-beta-hydroxysterols derived from mitochondrially-generated acetyl-CoA is ascribed to a loss of 3H in the citrate synthase reaction. The data showed that (1) fatty acids and 3-beta-hydroxysterols syntheses use the same pool of cytosolic acetyl-CoA; and (2) in the absence of an isotope effect in the citrate synthase reaction, mitochondrially-generated acetyl-CoA contributes about 36% to lipogenesis from acetate.
2.Pioglitazone, quercetin and hydroxy citric acid effect on hepatic biomarkers in Non Alcoholic Steatohepatitis.
Surapaneni KM;Jainu M Pharmacognosy Res. 2014 Apr;6(2):153-62. doi: 10.4103/0974-8490.129037.
BACKGROUND: ;Non alcoholic steatohepatitis (NASH), severe form of diseases belonging to the spectrum of the Non alcoholic fatty liver disease (NAFLD). It is an asymptomatic disease which leads to fibrosis and finally to cirrhosis, an end stage liver disease.;OBJECTIVE: ;To study the effect of pioglitazone, quercetin and hydroxy citric acid on hepatic biomarkers and various biochemical parameters in experimentally induced non alcoholic steatohepatitis (NASH).;MATERIALS AND METHODS: ;Male Wister rats were divided into 8 groups. The activities of alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) and γ-Glutamyl Transferase (GGT) were assayed in serum. The levels of various other biochemical parameters such as serum albumin, total bilirubin, creatinine, urea, uric acid and glucose were also estimated in experimental NASH.;RESULTS: ;The NASH group produced severe liver injury by significantly increasing the serum levels of ALT, AST, GGT and LDH compared with that of the control.
3.Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet.
Brandt K;Langhans W;Geary N;Leonhardt M Nutrition. 2006 Sep;22(9):905-12. Epub 2006 Jul 10.
OBJECTIVE: ;The present study assessed whether long-term supplementation of a high-fructose diet with hydroxycitrate (HCA), an inhibitor of de novo lipogenesis that is widely used as a non-prescription dietary aid, decreases food intake, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats.;METHODS: ;We examined the effects of HCA (1.8% of diet) on food intake, body weight gain, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats during a 4-wk period of ad libitum access to a 50% fructose diet after a 3-wk period of food restriction in which they lost about 20% of their body weight.;RESULTS: ;HCA decreased food intake and weight gain throughout the test and reduced visceral fat accumulation compared with control rats fed ad libitum (CON). Rats that were pair-fed (PF) to the HCA rats showed similar decreases in weight gain and visceral fat. HCA did not ameliorate the hypertriglyceridemia induced by high-fructose feeding.
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CAS 6205-14-7 Hydroxycitric acid

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