Hydroxychloroquine sulfate - CAS 747-36-4
Catalog number: 747-36-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H28ClN3O5S
Molecular Weight:
433.95
COA:
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Targets:
Toll-like Receptor (TLR)
Description:
TLR9 inhibitor; Autophagy inhibitor
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Brife Description:
TLR9 inhibitor; Autophagy inhibitor
Appearance:
White lyophilised solid
Synonyms:
2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Solubility:
Soluble to 100 mM in water
Storage:
Store at +4°C
MSDS:
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Quality Standard:
In-house
Quantity:
Grams-Kilos
Boiling Point:
516.7 °C at 760 mmHg
Melting Point:
240 °C
InChIKey:
JCBIVZZPXRZKTI-UHFFFAOYSA-N
InChI:
1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
Canonical SMILES:
CC(CCCN(CC)CCO)NC1=CC=NC2=CC(Cl)=CC=C21.O=S(O)(O)=O
1.Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease.
Berende A1, ter Hofstede HJ1, Vos FJ1, van Middendorp H1, Vogelaar ML1, Tromp M1, van den Hoogen FH1, Donders AR1, Evers AW1, Kullberg BJ1. N Engl J Med. 2016 Mar 31;374(13):1209-20. doi: 10.1056/NEJMoa1505425.
BACKGROUND: The treatment of persistent symptoms attributed to Lyme disease remains controversial. We assessed whether longer-term antibiotic treatment of persistent symptoms attributed to Lyme disease leads to better outcomes than does shorter-term treatment.
2.Hydroxychloroquine attenuates cigarette smoke induced autophagic signaling in the mouse ovary.
Furlong HC1, Wessels JM1, Guerra MT2, Stämpfli MR3, Foster WG4. Reprod Toxicol. 2016 Mar 29;61:105-113. doi: 10.1016/j.reprotox.2016.03.044. [Epub ahead of print]
We previously demonstrated that Cigarette Smoke (CS) induces autophagy in the ovary. Therefore we aimed to determine if chloroquine (CQ) could inhibit CS-induced autophagy in the ovary. Eight week old mice were implanted with CQ pellets; 0, 25, and 50mg CQ/kg. Half of the animals in each group were exposed to room air and the other half were exposed to CS twice daily for 8 weeks. Ovaries were harvested for electron microscopy, gene and protein expression analysis. There was a significant increase in the production of autophagosomes in granulosa cells of mice exposed to CS (p=0.0297). However 25 and 50mg/kg CQ treatment significantly decreased the CS-induced autophagosomes (p=0.0505; p=0.0065) and attenuated the effects of CS on LC3B and BECN1 expression. In summary, this suggests that CQ attenuates CS-induced autophagy in the ovary and that ovarian protection from toxic insult is potentially feasible.
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Chemical Structure

CAS 747-36-4 Hydroxychloroquine sulfate

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