Hydrocoumarin - CAS 119-84-6
Catalog number: 119-84-6
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H8O2
COA:
Inquire
Chemical Family:
Coumarins
Purity:
>98%
Appearance:
Powder
Synonyms:
2-Benzodihydropyrone; Hydrocoumarin; 3,4-Dihydrocoumarin;
MSDS:
Inquire
Quality Standard:
Enterprise Standard
Quantity:
Grams-Kilos
1.New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101.
Casellas M;Grifoll M;Bayona JM;Solanas AM Appl Environ Microbiol. 1997 Mar;63(3):819-26.
Identification of new metabolites and demonstration of key enzyme activities support and extend the pathways previously reported for fluorene metabolism by Arthrobacter sp. strain F101. Washed-cell suspensions of strain F101 with fluorene accumulated 9-fluorenone, 4-hydroxy-9-fluorenone, 3-hydroxy-1-indanone, 1-indanone, 2-indanone, 3-(2-hydroxyphenyl) propionate, and a compound tentatively identified as a formyl indanone. Incubations with 2-indanone produced 3-isochromanone. The growth yield with fluorene as a sole source of carbon and energy corresponded to an assimilation of about 34% of fluorene carbon. About 7.4% was transformed into 9-fluorenol, 9-fluorenone, and 4-hydroxy-9-fluorenone. Crude extracts from fluorene-induced cells showed 3,4-dihydrocoumarin hydrolase and catechol 2,3-dioxygenase activities. These results and biodegradation experiments with the identified metabolites indicate that metabolism of fluorene by Arthrobacter sp. strain F101 proceeds through three independent pathways. Two productive routes are initiated by dioxygenation at positions 1,2 and 3,4, respectively. meta cleavage followed by an aldolase reaction and loss of C-1 yield the detected indanones. Subsequent biological Baeyer-Villiger reactions produce the aromatic lactones 3,4-dihydrocoumarin and 3-isochromanone.
2.Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds.
Fry JR;Fentem JH;Salim A;Tang SP;Garle MJ;Whiting DA J Pharm Pharmacol. 1993 Mar;45(3):166-70.
The interaction of glutathione (GSH) with coumarin, or one of a series of compounds related to coumarin, was assessed in the absence and presence of liver microsomes (direct reaction and indirect reaction, respectively) to determine the structural requirements for direct and mono-oxygenase-mediated reaction of cyclic alpha,beta-unsaturated carbonyls with GSH. Acrolein was used as a positive control for the direct reaction, and produced complete or nearly complete depletion of GSH under all assay conditions. 5,6-Dihydro-2H-pyran-2-one and 2-cyclohexen-1-one also produced substantial depletion of GSH in the direct reaction, which was not increased by the addition of liver microsomes. Coumarin, 2H-pyran-2-one and precocene I (a substituted pyran lacking the 2-one structure) were not substrates for the direct reaction but did cause depletion of GSH when incubated in the presence of rat or human liver microsomes. These depletions were dependent on a functioning mono-oxygenase system as judged by the effects of omission of cofactors, addition of competitive or inactivating inhibitors of cytochrome P450, and induction. Dihydrocoumarin, delta-valerolactone, cyclohexanone and 4H-pyran-4-one were not substrates for either the direct or indirect reaction.
3.3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46.
Kataoka M;Honda K;Shimizu S Eur J Biochem. 2000 Jan;267(1):3-10.
A novel lactonohydrolase, an enzyme that catalyzes the hydrolysis of 3,4-dihydrocoumarin, was purified 375-fold to apparent homogeneity, with a 22.7% overall recovery, from Acinetobacter calcoaceticus F46, which was isolated as a fluorene-assimilating micro-organism. The molecular mass of the native enzyme, as estimated by high-performance gel-permeation chromatography, is 56 kDa, and the subunit molecular mass is 30 kDa. The enzyme specifically hydrolyzes 3,4-dihydrocoumarin, and the Km and Vmax for 3,4-dihydrocoumarin are 0.806 mM and 4760 U.mg-1, respectively. The N-terminal and internal amino acid sequences of the enzyme show high similarity to those of bacterial non-heme haloperoxidases. The enzyme exhibits brominating activity with monochlorodimedon in the presence of H2O2 and 3, 4-dihydrocoumarin or an organic acid, such as acetate and n-butyrate.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Coumarins Products


CAS 23733-95-1 trans-3'-O-Benzoyl-4'-O-methylkhellactone

trans-3'-O-Benzoyl-4'-O-methylkhellacton
(CAS: 23733-95-1)

trans-3'-O-Benzoyl-4'-O-methylkhellactone is a coumarin isolated from the roots of Peucedanum praeruptorum Dunn.

CAS 483-90-9 Toddalolactone

Toddalolactone
(CAS: 483-90-9)

Toddalolactone usually can be isolated from the roots of Toddalia asiatica Lam.

CAS 73069-25-7 praeruptorin A

praeruptorin A
(CAS: 73069-25-7)

Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2...

Praeroside II
(CAS: 86940-46-7)

Praeroside II is a natural coumarin found in several plants.<br/>

CAS 23733-92-8 trans-Methylkhellactone

trans-Methylkhellactone
(CAS: 23733-92-8)

trans-Methylkhellactone is a coumarin isolated from the roots of Peucedanum praeruptorum Dunn.

CAS 13895-92-6 Rutaretin

Rutaretin
(CAS: 13895-92-6)

Rutaretin is a natural coumarin found in the herbs of Ruta graveolens L.

CAS 485-90-5 Hydrangetin

Hydrangetin
(CAS: 485-90-5)

Hydrangetin is a coumarin isolated from the rhizome of Daphne papyracea var. crassiuscula.

CAS 31575-93-6 Heraclenol

Heraclenol
(CAS: 31575-93-6)

Heraclenol isolated from the herbs of Heracleum repula Franch. It inhibit the proliferation of melanoma cells and cell cycle.

CAS 112789-90-9 Osthenone

Osthenone
(CAS: 112789-90-9)

Osthenone is a coumarin isolated from Murraya exotica. Osthenone exhibits antiproliferative activity against several cancer cell lines.

CAS 161753-49-7 12-Oxocalanolide A

12-Oxocalanolide A
(CAS: 161753-49-7)

12-Oxocalanolide A is a chromanone derivative that is isolated from Calophyllum polyanthum. 12-Oxocalanolide A is identified as a HIV-1 reverse transcriptase (R...

CAS 120028-43-5 Edgeworin

Edgeworin
(CAS: 120028-43-5)

Edgeworin is a DNA polymerase beta (pol beta) inhibitor that inhibits both the lyase and polymerase activities of DNA polymerase beta. Edgeworin can be isolated...

CAS 50276-98-7 Erythrocentaurin

Erythrocentaurin
(CAS: 50276-98-7)

Erythrocentaurin is a natural coumarin compound found in several plants.

CAS 2543-94-4 Phellopterin

Phellopterin
(CAS: 2543-94-4)

Phellopterin is a natural coumarin compound found from Amyris pinnata, Phellopterus littoralis and Ferula alliacea ects.

CAS 2880-49-1 Heraclenin

Heraclenin
(CAS: 2880-49-1)

Heraclenin isolated from the fruits of Citrus aurantium L. It induces apoptosis in Jurkat leukemia cells.

CAS 5058-13-9 Columbianadin

Columbianadin
(CAS: 5058-13-9)

Columbianadin was found to possess strong inhibitory activity against the inflammatory response of IL-1β-treated A549 cells and LPS-treated MH-S cells. Columbia...

CAS 28095-18-3 Ulopterol

Ulopterol
(CAS: 28095-18-3)

CAS 94285-22-0 Acetyldihydromicromelin A

Acetyldihydromicromelin A
(CAS: 94285-22-0)

Acetyldihydromicromelin A comes from the herbs of Micromelum sp.

CAS 1432075-68-7 7-Geranyloxy-5-methoxycoumarin

7-Geranyloxy-5-methoxycoumarin
(CAS: 1432075-68-7)

7-Geranyloxy-5-methoxycoumarin can be found in the twigs of Toddalia asiatica.

CAS 479-13-0 Coumestrol

Coumestrol
(CAS: 479-13-0)

Coumestrol is a phytoestrogen found in soybeans, spinach, and clover, mimicking the biological activity of estrogens. Coumestrol binds to the ERα and Erβ to exh...

CAS 131652-35-2 8-(1-Chloro-2-hydroxy-3-methylbut-3-enyl)-7-methoxycoumarin

8-(1-Chloro-2-hydroxy-3-methylbut-3-enyl
(CAS: 131652-35-2)

8-(1-Chloro-2-hydroxy-3-methylbut-3-enyl)-7-methoxycoumarin is a coumarin compound that can be isolated from Murraya paniculata.

Chemical Structure

CAS 119-84-6 Hydrocoumarin

Quick Inquiry

Verification code

Featured Items