Hydrocortisone-17-butyrate - CAS 13609-67-1
Catalog number:
13609-67-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H36O6
Molecular Weight:
432.55
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Hydrocortisone-17-butyrate, a glucocorticoid compound, could be used as antiinflammatory and immunosuppresive agent.
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Purity:
95%
Appearance:
Powder
Synonyms:
11b,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate;11BETA,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 17-BUTYRATE;HYDROCORTISONE 17-BUTYRATE;HYDROCORTISONE BUTYRATE;CORTISOL 17-BUTYRATE;11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione17-alpha-butyrate
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Hydrocortisone-17-butyrate could be used as antiinflammatory and immunosuppresive agent.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
585.6ºC at 760mmHg
Density:
1.23g/cm3
InChIKey:
BMCQMVFGOVHVNG-TUFAYURCSA-N
InChI:
InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1
Canonical SMILES:
CCCC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)C(=O)CO
1.Allergic contact dermatitis caused by prednicarbate presenting as chronic hand eczema.
Otero-Rivas MM1, Ruiz-González I1, Pérez-Bustillo A1, Rodríguez-Prieto MÁ1. Contact Dermatitis. 2015 Jul;73(1):51-2. doi: 10.1111/cod.12374. Epub 2015 Apr 13.
2.Non steroid treatment for eczema: results from a controlled and randomized study.
De Waure C1, Cadeddu C, Venditti A, Barcella A, Bigardi A, Masci S, Virno G, Cammisa A, Ricciardi W. G Ital Dermatol Venereol. 2013 Oct;148(5):471-7.
AIM: This study assesses the efficacy of a new non steroid anti-inflammatory product in comparison to Hydrocortisone Butyrate 0.1% Cream in healing eczematous dermatitis.
3.Statistical design for formulation optimization of hydrocortisone butyrate-loaded PLGA nanoparticles.
Yang X1, Patel S, Sheng Y, Pal D, Mitra AK. AAPS PharmSciTech. 2014 Jun;15(3):569-87. doi: 10.1208/s12249-014-0072-4. Epub 2014 Feb 7.
The aim of this investigation was to develop hydrocortisone butyrate (HB)-loaded poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) with ideal encapsulation efficiency (EE), particle size, and drug loading (DL) under emulsion solvent evaporation technique utilizing various experimental statistical design modules. Experimental designs were used to investigate specific effects of independent variables during preparation of HB-loaded PLGA NP and corresponding responses in optimizing the formulation. Plackett-Burman design for independent variables was first conducted to prescreen various formulation and process variables during the development of NP. Selected primary variables were further optimized by central composite design. This process leads to an optimum formulation with desired EE, particle size, and DL. Contour plots and response surface curves display visual diagrammatic relationships between the experimental responses and input variables.
4.Allergic contact dermatitis induced by topical hydrocortisone-17-butyrate mimicking papular rosacea.
D'Erme AM, Gola M. Dermatitis. 2012 Mar-Apr;23(2):95-6. doi: 10.1097/DER.0b013e31824a609f.
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CAS 13609-67-1 Hydrocortisone-17-butyrate

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