Hydrocortisone-17-butyrate - CAS 13609-67-1
Catalog number: 13609-67-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H36O6
Molecular Weight:
432.55
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Hydrocortisone-17-butyrate, a glucocorticoid compound, could be used as antiinflammatory and immunosuppresive agent.
Purity:
95%
Appearance:
Powder
Synonyms:
11b,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate;11BETA,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 17-BUTYRATE;HYDROCORTISONE 17-BUTYRATE;HYDROCORTISONE BUTYRATE;CORTISOL 17-BUTYRATE;11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione17-alpha-butyrate
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Hydrocortisone-17-butyrate could be used as antiinflammatory and immunosuppresive agent.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
585.6ºC at 760mmHg
Density:
1.23g/cm3
InChIKey:
BMCQMVFGOVHVNG-TUFAYURCSA-N
InChI:
InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1
Canonical SMILES:
CCCC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)C(=O)CO
1.Allergic contact dermatitis caused by prednicarbate presenting as chronic hand eczema.
Otero-Rivas MM1, Ruiz-González I1, Pérez-Bustillo A1, Rodríguez-Prieto MÁ1. Contact Dermatitis. 2015 Jul;73(1):51-2. doi: 10.1111/cod.12374. Epub 2015 Apr 13.
2.Non steroid treatment for eczema: results from a controlled and randomized study.
De Waure C1, Cadeddu C, Venditti A, Barcella A, Bigardi A, Masci S, Virno G, Cammisa A, Ricciardi W. G Ital Dermatol Venereol. 2013 Oct;148(5):471-7.
AIM: This study assesses the efficacy of a new non steroid anti-inflammatory product in comparison to Hydrocortisone Butyrate 0.1% Cream in healing eczematous dermatitis.
3.Statistical design for formulation optimization of hydrocortisone butyrate-loaded PLGA nanoparticles.
Yang X1, Patel S, Sheng Y, Pal D, Mitra AK. AAPS PharmSciTech. 2014 Jun;15(3):569-87. doi: 10.1208/s12249-014-0072-4. Epub 2014 Feb 7.
The aim of this investigation was to develop hydrocortisone butyrate (HB)-loaded poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) with ideal encapsulation efficiency (EE), particle size, and drug loading (DL) under emulsion solvent evaporation technique utilizing various experimental statistical design modules. Experimental designs were used to investigate specific effects of independent variables during preparation of HB-loaded PLGA NP and corresponding responses in optimizing the formulation. Plackett-Burman design for independent variables was first conducted to prescreen various formulation and process variables during the development of NP. Selected primary variables were further optimized by central composite design. This process leads to an optimum formulation with desired EE, particle size, and DL. Contour plots and response surface curves display visual diagrammatic relationships between the experimental responses and input variables.
4.Allergic contact dermatitis induced by topical hydrocortisone-17-butyrate mimicking papular rosacea.
D'Erme AM, Gola M. Dermatitis. 2012 Mar-Apr;23(2):95-6. doi: 10.1097/DER.0b013e31824a609f.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 72795-01-8 ICI 118551 hydrochloride

ICI 118551 hydrochloride
(CAS: 72795-01-8)

ICI 118551 hydrochloride is a highly selective β2 adrenergic antagonist (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively), inhibited ...

TAK-259 HCl
(CAS: 1192347-42-4)

This active molecular is a selective α1D Adrenergic Receptor antagonist. ( Ki value of 1.1 nM, 200 fold selective over α1A and 800 fold selective over α1B). TAK...

CAS 32780-64-6 labetalol hydrochloride

labetalol hydrochloride
(CAS: 32780-64-6)

Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure...

CAS 94-07-5 Synephrine

Synephrine
(CAS: 94-07-5)

Synephrine is an α-adrenergic receptor agonist used as a vasoconstrictor.

CAS 503070-58-4 Vilanterol trifenatate

Vilanterol trifenatate
(CAS: 503070-58-4)

Vilanterol, also known as GW-642444, is a long-acting beta-2 agonist drug, which in May 2013 was approved in combination with fluticasone furoate for sale as Br...

CAS 66711-21-5 Apraclonidine

Apraclonidine
(CAS: 66711-21-5)

Apraclonidine is a clonidine derivative with relatively selective alpha-2-adrenergic agonistic activity. It is an α2 adrenergic receptor agonist and a weak α1 a...

CAS 69906-86-1 Cyanopindolol hemifumarate

Cyanopindolol hemifumarate
(CAS: 69906-86-1)

Cyanopindolol hemifumarate is the hemifumarate salt of cyanopindolol, which is a 5-HT1A/1B antagonist. It is also a β-adrenoceptor antagonist. It has roughly eq...

CAS 83688-84-0 Tertatolol

Tertatolol
(CAS: 83688-84-0)

Tertatolol, a benzothiopyran derivative, is a potent dual antagonist of beta-adrenoceptor and 5-HT receptor, with antihypertensive effect.

AdTx1

AdTx1 is a high affinity, selective and non-competitive α1A adrenoceptor antagonist with Ki value of 0.35 nM. It is a 65 amino-acid peptide originally isolated ...

CAS 39731-05-0 SDZ 21009

SDZ 21009
(CAS: 39731-05-0)

SDZ 21009 is a β-adrenoceptor and 5-HT1A/1B receptor antagonist (pKB/pA2 = 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors, respectively).

CAS 804518-03-4 Milveterol hydrochloride

Milveterol hydrochloride
(CAS: 804518-03-4)

Milveterol is a long-acting β(2)-adrenoceptor agonist under the development of GlaxoSmithKline. Phase II trials for the treatment of Chronic obstructive pulmona...

CAS 93379-54-5 (S)-(-)-Atenolol

(S)-(-)-Atenolol
(CAS: 93379-54-5)

(S)-(-)-Atenolol is the active enantiomer of (RS)-atenolol, which is a cardioselective β-adrenergic blocker. It has antihypertensive, antianginal, antiarrhythmi...

Bopindolol Malonate
(CAS: 62658-64-4)

Bopindolol Malonate is a potent, non-selective, long-acting beta adrenoceptor antagonist. It demonstrates inhibition of H2O2-induced lipid peroxdiation. It is a...

CAS 57754-86-6 Nisoxetine hydrochloride

Nisoxetine hydrochloride
(CAS: 57754-86-6)

Nisoxetine hydrochloride is a high affinity (IC50 = 1 nM) inhibitor of the presynaptic norepinephrine<br/>(NE) reuptake system, with little or no affinity for a...

CAS 245744-10-9 RWJ 52353

RWJ 52353
(CAS: 245744-10-9)

RWJ 52353 is an α2 agonist with analgesic activity (Ki= 1.5, 254, 443 and 621 nM for α2D, α2A, α1 and α2B adrenergic receptors respectively).

CAS 55974-42-0 ARC 239 dihydrochloride

ARC 239 dihydrochloride
(CAS: 55974-42-0)

The hydrochloride salt form of ARC 239, which has been found to be an α2B adrenoceptor antagonist as well as a norepinephrine-serotonin reuptake inhibitor.

CAS 158599-53-2 Zoleprodolol

Zoleprodolol
(CAS: 158599-53-2)

Zoleprodolol, an oxadiazol derivative, has been found to be an adrenergic receptor antagonist.

(RS)-Butyryltimolol

(RS)-Butyryltimolol is the racemate of Butyryltimolol which is the butyryl ester of Timolol. Timolol, in the non-selective β blocker family of medication, has b...

CAS 7361-61-7 Xylazine

Xylazine
(CAS: 7361-61-7)

Xylazine is an analogue of clonidine, which is an agonist at the α2 class of adrenergic receptor. It is a drug used for sedation, anesthesia, muscle relaxation ...

CAS 179388-65-9 AH 11110 hydrochloride

AH 11110 hydrochloride
(CAS: 179388-65-9)

The hydrochloride salt form of AH 11110, which is an α1B-adrenoceptor ligand and has been found to exhibit interaction with α1-adrenoceptors as well as α2-adren...

Chemical Structure

CAS 13609-67-1 Hydrocortisone-17-butyrate

Quick Inquiry

Verification code

Featured Items