Hydrastinine hydrochloride - CAS 4884-68-8
Catalog number:
4884-68-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H14ClNO3
Molecular Weight:
243.69
COA:
Inquire
Targets:
Others
Description:
Hydrastinine hydrochloride is a semisynthetic alkaloid as a haemostatic drug.
Publictions citing BOC Sciences Products
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Purity:
≥98%
Appearance:
White powder
Synonyms:
6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol;hydrochloride;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Semisynthetic alkaloid
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
199-203 °C
InChIKey:
DLNQCQJCIITVHC-UHFFFAOYSA-N
InChI:
1S/C11H13NO3.ClH/c1-12-3-2-7-4-9-10(15-6-14-9)5-8(7)11(12)13;/h4-5,11,13H,2-3,6H2,1H3;1H
Canonical SMILES:
CN1CCC2=CC3=C(C=C2C1O)OCO3.Cl
Current Developer:
Bayer
1.Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine.
Inbaraj JJ1, Kukielczak BM, Bilski P, He YY, Sik RH, Chignell CF. Chem Res Toxicol. 2006 Jun;19(6):739-44.
Goldenseal is an herb that is widely used in dietary supplements, eye washes, and skin lotions. The presence of Goldenseal root powder in dietary supplements and the topical application of Goldenseal preparations raise the possibility that an adverse phototoxic reaction may result from an interaction between its constituent alkaloids and light in exposed tissues. We have previously shown that berberine, the major alkaloid in Goldenseal powder, in combination with UVA causes DNA damage and cell death in HaCaT keratinocytes [(2001) Chem. Res. Toxicol. 14, 1529]. We have studied the photochemical and photobiological properties of four minor alkaloids found in Goldenseal, namely, hydrastine, palmatine, canadine, and hydrastinine. UVA radiation of palmatine in aqueous solutions generated no (1)O(2), but in CH(2)Cl(2), copious amounts of (1)O(2) were detected (Phi = 0.2). Palmatine also photogenerated oxygen-centered radicals, (*)OH and O(2)(*)(-) in aerated aqueous buffer and acetonitrile, respectively, as detected by the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO).
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CAS 4884-68-8 Hydrastinine hydrochloride

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