|Description||HX-603 is a RXR agonist.|
|Appearance||White to Off-White Solid|
|Synonyms||4-(7,7,10,10-tetramethyl-5-propyl-8,9-dihydronaphtho[2,3-b][1,5]benzodiazepin-12-yl)benzoic acid; HX-603; HX 603; HX603|
|Boiling Point||483.2±40.0 ℃ at 760 mmHg|
A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs = 2-5 nM) inhibited colony formation (by 50%) by all three lines at 16-34 nM, and led to...
ER 50891 is an RARα receptor antagonist (IC50 = 31.2 nM).
HX 531 is a potent RXR antagonist (IC50 = 18 nM) that inhibits 9-cis retinoic acid-induced transactivation of RXR. HX 531 promotes the differentiation of white ...
HX-603 is a RXR agonist.
LG 101506 is a selective RXR modulator.
Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
SR 11237 is a pan retinoid X receptor (RXR) agonist with no RAR activity.
BMS 753 is a RARα-selective agonist (Ki = 2 nM) that modulates the ATRA-inducible cytochrome P450 26A1 (CYP26A1).
LY2955303 is a selective Retinoic acid receptor gamma (RAR-γ) antagonist with Ki of 1.09 nM; (RAR-α Ki > 1700 nM; RAR-β Ki > 2980 nM). LY2955303 showed good pha...
CD 2665 is a selective RARβ and RARγ antagonist (KD = 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively) with no activity at RXRα. CD 2665 is used to ...
Adapalene sodium salt
Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). It is a third-generation topical retinoid primarily used in the treatmen...
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist that enhances interaction of nuclear corepressor (NCoR) and RARs.
RX-195183 is an RARα agonist (Kd=3 nM) with potential antineoplastic activity, modulating the transcription of genes responsible for cell differentiation and pr...
LG 100268 is a retinoid X receptor agonist with EC50 value of 4 nM. It can inhibit vinyl carbamate-induced lung tumor growth in mice in vivo.
Ch 55 is a highly potent synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. It has high affinity for RAR-α and RAR-β receptors, ...
CD 2314 is a potent and selective RARβ receptor agonist (Kd = 145 and >3760 nM for RARβ and RARα receptors, respectively).
BMS 195614 is a neutral RAR α-selective antagonist (Ki = 2.5 nM) and exhibits no significant effect on nuclear receptor corepressor (NCoR) binding. BMS 195614 m...
BMS 270394 is a nuclear retinoic acid receptor (RAR-γ) agonist.
CD 3254 is a selective RXRα agonist with no activity at RARα, RARβ or RARγ receptors.
Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors).