(±)-Huperzine A - CAS 120786-18-7
Catalog number: 120786-18-7
Category: Inhibitor
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Molecular Formula:
C15H18N2O
Molecular Weight:
242.32
COA:
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Targets:
AChE
Description:
Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
Purity:
>98%
Synonyms:
Huperzine A
MSDS:
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InChIKey:
ZRJBHWIHUMBLCN-QDEBKDIKSA-N
InChI:
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
Canonical SMILES:
CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3
1.Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research.
Damar U1, Gersner R1, Johnstone JT2, Schachter S3, Rotenberg A1. Expert Rev Neurother. 2016 Apr 20:1-10. [Epub ahead of print]
Huperzine A (HupA) is an acetylcholinesterase (AChE) inhibitor extracted from Huperzia Serrata, a firmoss, which has been used for various diseases in traditional Chinese medicine for fever and inflammation. More recently, it has been used in Alzheimer's disease and other forms of dementia with a presumed mechanism of action via central nicotinic and muscarinic receptors. HupA is marketed as a dietary supplement in the U.S. This article reviews newly proposed neuroprotective and anticonvulsant HupA properties based on animal studies. HupA exerts its effects mainly via α7nAChRs and α4β2nAChRs, thereby producing a potent anti-inflammatory response by decreasing IL-1β, TNF-α protein expression, and suppressing transcriptional activation of NF-κB signaling. Thus, it provides protection from excitotoxicity and neuronal death as well as increase in GABAergic transmission associated with anticonvulsant activity.
2.Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice.
Zuo ZX1, Wang YJ2, Liu L3, Wang Y3, Mei SH3, Feng ZH2, Wang M4, Li XY3. Neural Plast. 2015;2015:453170. doi: 10.1155/2015/453170. Epub 2015 Dec 1.
Chronic pain is a major health issue and most patients suffer from spontaneous pain. Previous studies suggest that Huperzine A (Hup A), an alkaloid isolated from the Chinese herb Huperzia serrata, is a potent analgesic with few side effects. However, whether it alleviates spontaneous pain is unclear. We evaluated the effects of Hup A on spontaneous pain in mice using the conditioned place preference (CPP) behavioral assay and found that application of Hup A attenuated the mechanical allodynia induced by peripheral nerve injury or inflammation. This effect was blocked by atropine. However, clonidine but not Hup A induced preference for the drug-paired chamber in CPP. The same effects occurred when Hup A was infused into the anterior cingulate cortex. Furthermore, ambenonium chloride, a competitive inhibitor of acetylcholinesterase, also increased the paw-withdrawal threshold but failed to induce place preference in CPP. Therefore, our data suggest that acetylcholinesterase in both the peripheral and central nervous systems is involved in the regulation of mechanical allodynia but not the spontaneous pain.
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CAS 120786-18-7 (±)-Huperzine A

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