Humantenine - CAS 82375-29-9
Catalog number: 82375-29-9
Not Intended for Therapeutic Use. For research use only.
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Humantenine may be found in the roots of Gelsemium elegans.
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1.Large-scale separation of alkaloids from Gelsemium elegans by pH-zone-refining counter-current chromatography with a new solvent system screening method.
Fang L;Zhou J;Lin Y;Wang X;Sun Q;Li JL;Huang L J Chromatogr A. 2013 Sep 13;1307:80-5. doi: 10.1016/j.chroma.2013.07.069. Epub 2013 Jul 23.
A rapid and simple solvent system screening method was developed for pH-zone-refining counter-current chromatography (CCC) separation, which was much easier to find a suitable solvent system than the traditional method. Using this method, an optimal solvent system composed of hexane-ethyl acetate-methanol-water (3:7:1:9, v/v) was selected for pH-zone-refining CCC separation of alkaloids from the stems of Gelsemium elegans, where 10mM triethylamine (TEA) was added to the upper organic stationary phase as a retainer and 10mM hydrochloric acid (HCl) to the aqueous mobile phase as an eluter. As a result, six oxindole alkaloids, 420mg 19-xo-gelsenicine, 456mg gelsemine, 723mg koumine, 379mg 11-methoxygelsemamide, 342mg gelsenicine and 318mg humantenine were successfully purified in one step from 4.5g crude extract with the purity of over 95%, respectively. The structures of the oxindole alkaloids were identified by ESI-MS, (1)H NMR and (13)C NMR.
2.New humantenine-type alkaloids from Gelsemium elegans.
Lin LZ;Cordell GA;Ni CZ;Clardy J J Nat Prod. 1989 May-Jun;52(3):588-94.
The alkaloid extract of the whole plant of Gelsemium elegans has afforded four new alkaloids: N-desmethoxyrankinidine [1], 11-hydroxrankinidine [3], 11-hydroxyhuman-humantenine [4] and humantenirine [6]. The structures of 5 was established through X-ray crystallographic analysis, and the structures of the other three new alkaloids were deduced by spectral analysis (1H, 13C, APT, 2D-COSY and 2D-HETCOR).
3.Inhibitory effects of cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots.
Wang Y;Wu S;Chen Z;Zhang H;Zhao W J Ethnopharmacol. 2015 May 26;166:66-73. doi: 10.1016/j.jep.2015.03.002. Epub 2015 Mar 10.
ETHNOPHARMACOLOGICAL RELEVANCE: ;Gelsemium elegans (GE), widely distributed in East Asia, South East Asia and Northern America, is a kind of well-known toxic plant throughout the world. Yet it has been used as a Chinese folk medicine for treatment of malignant tumors, pain, rheumatic arthritis, psoriasis and immune function.;AIM OF THE STUDY: ;The present study was to investigate the potential inhibitory effects of G. elegans (GE) roots on four major cytochrome P450 (CYP450) isoforms (CYP1A2, CYP2A6, CYP2E1 and CYP3A4) in vitro.;MATERIALS AND METHODS: ;Four extracts (petroleum ether, dichloromethane, EtOAc and aqueous) of GE and two commercially available alkaloids (koumine and humantenmine) were screened for their CYP isoforms inhibitory activity. Four enzyme inhibition assays were examined according to the method of the literature. Phenacetin, coumarin, chlorzoxazone and testosterone were used as probe substrates in order to determine CYP1A2, CYP2A6, CYP2E1 and CYP3A4 catalytic activity, respectively.
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CAS 82375-29-9 Humantenine

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