|Targets||Hsp90 | HSP|
|Description||Hsp980 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp980 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.|
|Brife Description||NVP-Hsp980 is an orally available Hsp90 inhibitor and is structurally different from other clinical Hsp90 inhibitors.|
|Solubility||DMSO > 10 mM|
|Storage||3 years -20oC powder, 6 months-80oC in solvent.|
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