Hsp990 - CAS 934343-74-5
Catalog number:
934343-74-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H18FN5O2
Molecular Weight:
379.39
COA:
Inquire
Targets:
Hsp90 | HSP
Description:
Hsp980 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.  Hsp980 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.
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Brife Description:
NVP-Hsp980 is an orally available Hsp90 inhibitor and is structurally different from other clinical Hsp90 inhibitors.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
NVP-Hsp990.
Solubility:
DMSO > 10 mM
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
WSMQUUGTQYPVPD-OAHLLOKOSA-N
InChI:
InChI=1S/C20H18FN5O2/c1-10-18-16(26-20(22)23-10)9-15(25-19(18)27)12-7-6-11(21)8-13(12)14-4-3-5-17(24-14)28-2/h3-8,15H,9H2,1-2H3,(H,25,27)(H2,22,23,26)/t15-/m1/s1
Canonical SMILES:
CC1=NC(=NC2=C1C(=O)NC(C2)C3=C(C=C(C=C3)F)C4=NC(=CC=C4)OC)N
Current Developer:
Novartis
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CAS 934343-74-5 Hsp990

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