Homosalate - CAS 118-56-9
Catalog number:
118-56-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H22O3
Molecular Weight:
262.35
COA:
Inquire
Targets:
Others
Description:
Homosalate could be commonly useful in sorts of cosmetics acting as a chemical UV filter.
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Purity:
98%
Appearance:
Viscous or light yellow to slightly tan liquid or oil.
Synonyms:
SALICYLIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER;trimethylcyclohenyl salicylate;Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester;Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester;component of Coppertone;Coppertone;Filtersol ''A'';Filtrosol A
Solubility:
DMSO:55mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Homosalate could be commonly useful in sorts of cosmetics acting as a chemical UV filter.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Density:
1.1 g/cm3
InChIKey:
WSSJONWNBBTCMG-UHFFFAOYSA-N
InChI:
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3
Canonical SMILES:
CC1CC(CC(C1)(C)C)OC(=O)C2=CC=CC=C2O
1.Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue b
Jiménez-Díaz I1, Molina-Molina JM, Zafra-Gómez A, Ballesteros O, Navalón A, Real M, Sáenz JM, Fernández MF, Olea N. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 1;936:80-7. doi: 10.1016/j.jchromb.2013.08.006. Epub 2013 Aug 8.
UV-filters are widely used in many personal care products and cosmetics. Recent studies indicate that some organic UV-filters can accumulate in biota and act as endocrine disruptors, but there are few studies on the occurrence and fate of these compounds in humans. In the present work, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to assess the presence of six UV-filters in current use (benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor, and 3-benzylidene camphor) in human placental tissue is proposed. The method involves the extraction of the analytes from the samples using ethyl acetate, followed by a clean-up step using centrifugation prior to their quantification by LC-MS/MS using an atmospheric pressure chemical ionization (APCI) interface. Bisphenol A-d16 was used as surrogate for the determination of benzyl salicylate, phenyl salicylate, octyl salicylate and homosalate in negative mode and benzophenone-d10, was used as surrogate for the determination of 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in positive mode.
2.Interaction mechanisms between organic UV filters and bovine serum albumin as determined by comprehensive spectroscopy exploration and molecular docking.
Ao J1, Gao L2, Yuan T3, Jiang G4. Chemosphere. 2015 Jan;119:590-600. doi: 10.1016/j.chemosphere.2014.07.019. Epub 2014 Aug 14.
Organic UV filters are a group of emerging PPCP (pharmaceuticals and personal care products) contaminants. Current information is insufficient to understand the in vivo processes and health risks of organic UV filters in humans. The interaction mechanism of UV filters with serum albumin provides critical information for the health risk assessment of these active ingredients in sunscreen products. This study investigates the interaction mechanisms of five commonly used UV filters (2-hydroxy-4-methoxybenzophenone, BP-3; 2-ethylhexyl 4-methoxycinnamate, EHMC; 4-methylbenzylidene camphor, 4-MBC; methoxydibenzoylmethane, BDM; homosalate, HMS) with bovine serum albumin (BSA) by spectroscopic measurements of fluorescence, circular dichroism (CD), competitive binding experiments and molecular docking. Our results indicated that the fluorescence of BSA was quenched by these UV filters through a static quenching mechanism. The values of the binding constant (Ka) ranged from (0.
3.Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats.
Kim TH1, Shin BS, Kim KB, Shin SW, Seok SH, Kim MK, Kim EJ, Kim D, Kim MG, Park ES, Kim JY, Yoo SD. J Toxicol Environ Health A. 2014;77(4):202-13. doi: 10.1080/15287394.2013.861376.
Homosalate (HMS) is an ultraviolet (UV) filtering agent used in sunscreens and other cosmetics for skin protection purposes. Despite the widespread use of these products, absorption, disposition, and in vivo endocrine disrupting potential of HMS have not been characterized. Thus, the aim of this study was to examine the percutaneous absorption, disposition, and exposure assessment of HMS in rats. Initially, sunscreen preparations of petrolatum jelly, oily solution, lotion, and gel were prepared and evaluated for in vitro permeation of HMS across excised rat skin. Dermal permeability was greatest for gel, and this preparation was used in subsequent in vivo topical application investigations. After iv injection (0.5, 2, or 5 mg/kg), the pharmacokinetics of HMS was linear and was characterized by a large Vd(ss) (13.2-17 L/kg), high Cl(s) (4.5-6.1 L/h/kg), and long t½ (6.1-8.4 h). After topical application of gel, the bioavailability of HMS was 5.
4.Lichenic extracts and metabolites as UV filters.
Lohézic-Le Dévéhat F1, Legouin B, Couteau C, Boustie J, Coiffard L. J Photochem Photobiol B. 2013 Mar 5;120:17-28. doi: 10.1016/j.jphotobiol.2013.01.009. Epub 2013 Jan 26.
Three lichen extracts and ten lichenic compounds have been screened for their photoprotective activities. The determination of their Sun Protection Factor (SPF) and Protection Factor-UVA (PF-UVA) values was done in vitro. Among them, a Lasallia pustulata extract and gyrophoric acid exhibited SPF values over 5, which is better than Homosalate (SPF≈4). Their photoprotective properties are only slightly modified after a 2-hours period of irradiation. Salazinic acid and L. pustulata presented characteristics of a UVA booster like the butyl-methoxydibenzoylmethane (Avobenzone) (PF-UVA≈2 vs. 2.8 for Avobenzone). Salazinic acid was a better anion superoxide scavenger than ascorbic acid and none of them exhibited a photosensitizing cytotoxicity by exposing them on HaCaT cells to UVA radiations (photo-irritancy factor PIF<5).
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Chemical Structure

CAS 118-56-9 Homosalate

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