HM-30181 hydrochloride - CAS 849675-88-3
Catalog number:
849675-88-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C38-H36-N6-O7.Cl-H
Molecular Weight:
725.20
COA:
Inquire
Targets:
P-glycoprotein
Description:
HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials.
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Purity:
98%
Appearance:
Powder
Synonyms:
N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide hydrochloride
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
enhance the oral bioavailability of P-gp substrate drugs
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
KAQQJKZDBBMBEZ-UHFFFAOYSA-N
InChI:
1S/C38H36N6O7.ClH/c1-47-32-17-24-14-16-43(22-25(24)18-33(32)48-2)15-13-23-9-11-26(12-10-23)44-41-37(40-42-44)28-19-34(49-3)35(50-4)20-29(28)39-38(46)36-21-30(45)27-7-5-6-8-31(27)51-36;/h5-12,17-21H,13-16,22H2,1-4H3,(H,39,46);1H
Canonical SMILES:
COc1cc2c(cc1OC)CN(CC2)CCc3ccc(cc3)n4nc(nn4)c5cc(c(cc5NC(=O)c6cc(=O)c7ccccc7o6)OC)OC.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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