|Description||HLM 006474 acts as an E2F transcription factor inhibitor, preventing DNA binding activity. This results in the induction of apoptosis in breast cancer cells.|
|Synonyms||HLM 006474; HLM-006474|
Benserazide HCl is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.
AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycine...
Warfarin is an anticoagulant applicated in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migrati...
Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any ...
Phenamil, a second generation analog of amiloride (hydrochloride), inhibits TRPP3-mediated currents (IC50 = 0.14 μM) and also inhibits epithelial Na+ channels (...
Aminophenazone (or aminopyrine) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis.
MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic mem...
Caftaric acid is a natural productwhich was reported as an inhibitor of the protein-protein interactions mediated by the Src-family kinases.
Sulfoxone sodium is an anti-leprosy drug which was introduced in Japan in 1948.
R-(-)-Arundic Acid, also called as ONO 2506, is an astrocyte modulating agent which can treat neurodegenerative diseases including Alzheimer's disease and Parki...
Orphanin FQ (1-11)
Orphanin FQ is a NOP agonist and it shows analgesic properties.
Lalistat 1 is a lysosomal acid lipase inhibitor with IC50 value of 68 nM. It can block LAL-mediated lipid hydrolysis of acetylated LDL and reduce efflux of chol...
Curdione, a sesquiterpene compound, could probably be a candidate for inflammatory study and cancer chemopreventive agents.
Gap 26 is a gap junction blocker which is corresponding to residues 63 - 75 of connexin 43. Gap 26 was shown to attenuate rhythmic contractile activity of rabbi...
Resiniferonol 9,13,14-Orthophenylacetate, a 20-Deacylated derivative of resiniferatoxin and tinyatoxin, is a transient receptor potential vanilloid-1 (TRPV1) ag...
The oxalate salt form of Butabindide, which is a CCK-inactivating serine protease inhibitor.
Betaine is used to treat homocystinuria.
D-AP4 has been found to be an excitatory amino acid receptor antagonist as well as an agonist at the quisqualate-sensitized AP6 site.
Leflunomideinhibits the reproduction of rapidly dividing cells by inhbiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH).
Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denatur...