|Description||HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.|
|Brife Description||Hdm2 ubiquitin ligase (E3) inhibitor|
|Purity||≥99% by HPLC|
|Synonyms||HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride|
A natural compound, source from roots of Dioscorea opposita Thunb, could block the volt dependent form calcium channel in cellular membrane, and up-regulate the...
Ginsenoside Rg6, extracted from steamed notoginseng, exhibited significantly potent inhibitory effects on IL-12 p40 production in LPSstimulated BMDCs.
Protopanaxdiol is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin extracted from the roots of Panax ginseng C. A. Mey. It is an apop...
Episilvestrol is a derivative of Silvestrol, which is a member of flavagline family of natural products from the genus of Aglaia,
Apoptosis Activator 2
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. It ...
SCH 529074 is a small molecule activator of mutant p53 that binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants...
Elesclomol is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic...
Desacetylcinobufotalin is apoptosis inducer. shows the inhibition effect to HepG2 cells (IC50 =0.0279μmol/ml) .