HLCL65 hydrochloride
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C23H23BrN2O.HCl
Molecular Weight:
459.81
COA:
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Targets:
Others
Description:
HLCL65 hydrochloride is a first-in-class inhibitor of PRMT5. HLCL65 selectively inhibits Th1 cell proliferation (IC50 value 1.1 μM). In vivo, HLCL65 suppresses recall T cell responses and reduces inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models; In vitro, HLCL65 effectively inhibits symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.
Brife Description:
PRMT5 inhibitor
Purity:
99%
Synonyms:
HLCL65 hydrochloride; HLCL 65 hydrochloride; HLCL-65 hydrochloride; 1-(6-bromo-9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine hydrochloride
MSDS:
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InChIKey:
RCHOCKASSZYCEX-UHFFFAOYSA-N
InChI:
InChI=1S/C23H23BrN2O.ClH/c1-3-26-21-10-8-16(12-19(21)20-13-18(24)9-11-22(20)26)14-25-15-17-6-4-5-7-23(17)27-2;/h4-13,25H,3,14-15H2,1-2H3;1H
Canonical SMILES:
CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=C1C=CC(=C4)Br.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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