Higenamine - CAS 5843-65-2
Catalog number: 5843-65-2
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H17NO3
Molecular Weight:
271.31
COA:
Inquire
Chemical Family:
Alkaloids
Description:
Higenamine acts through inhibition of middle cerebral artery occlusion (MCAO)-mediated HMGB1 release in vivo. It is useful towards ischemic injuries.
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Purity:
>98%
Appearance:
White crystalline powder
Synonyms:
Demethyl-Coclaurine; DL-Demethylcoclaurine; Norcoclaurine; 1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol; 1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol; 1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquinolinediol; HigenaMine HydrobroMide Salt
MSDS:
Inquire
Application:
Anti-inflammatory/anti-arrhythmic
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
1. Higenamine regulates Nrf2-HO-1-Hmgb1 axis and attenuates intestinal ischemia–reperfusion injury in mice
Chao Liu • Chenyu Zhu • Guangsheng Wang • Rui Xu • Yaoming Zhu. Inflamm. Res. (2015) 64:395–403
Some animals received Higenamine (10 mg/kg, i.p.) just before reperfusion. In ZnPPIX-treated animal study, ZnPPIX (10 mg/kg, i.p.) was administrated 30 min before Higenamine treatment. In some groups, anti-Hgmb1 antibody (6 mg/kg, i.p.) was administrated just before reperfusion. For animal experiments using recombinant Hmgb1 (rHmgb1), animals received an intravenous bolus (tail vein) injection of 100 ng/ml of rHmgb1 (R&D Systems, Minneapolis, MN). Animals received rHmgb1 injection 1 h after IR.
2. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways
Yu Mi Ha • Min Young Kim • Min Kyu Park. Apoptosis (2012) 17:463–474
Higenamine (1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol), an active ingredient of Aconite tuber, has been traditionally used as cardiac inotropic and anti-inflammatory agents in oriental countries. Recently, we reported that higenamine reduced rat I/R-induced myocardial damage which was dependent on HO-1 activity. In addition, higenamine inhibits platelet aggregation and has anti-thrombotic effect which may be additionally beneficial on hypoxic-injury such as stroke. Because neurons are less equipped than glial cells in terms of defense against free radicals, glial cells may play an important role in response to ischemic stroke. The C6 glial cell is well characterized as a permanent cell line which readily differentiates and responds to stimulation with inflammatory cytokines. The C6 cells also express glial fibrillary acidic protein (GFAP), and upregulate GFAP expression following treatment with toxins in a manner similar to that seen in primary rat astrogliaso that it provides a good model for investigation of glial cell function.
3. Quantitative analysis and formulation development of a traditional Thai antihypertensive herbal recipe
Tossaton Charoonratana • Thanapat Songsak • Chaowalit Monton. Phytochem Rev (2014) 13:511–524
In a fingerprint of ESI-positive aqueous TTAH extract, three compounds were identified, including higenamine (m/z 271.0), salsolinol (m/z 179.1), and adenosine (m/z 267.0). It was found that higenamine, salsolinol, and adenosine wereminor compounds from the aqueous extract of T. crispa. Reports indicated that these compounds can decrease blood pressure via adrenoreceptors and the purinergic adenosine A2 and P2 receptors (Praman et al. 2011, 2012). The pharmacological activities of the plant extracts and their compounds were reviewed and used to support the use of TTAH. In general, the herbs comprising the recipe exhibit antihypertensive, anti-inflammatory, hepatoprotective, antioxidant, antidiabetic, antiobesity, and diuretic properties. Piperine, imperatorin, higenamine, salsolinol, and adenosine may work in concert to reduce blood pressure. Imperatorin, pinocembrin, verbascoside and C. rotundus extract are also highlighted for their anti-inflammatory effects, which can be related to detoxification.
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CAS 5843-65-2 Higenamine

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