Heparin sodium - CAS 9041-08-1
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Not Intended for Therapeutic Use. For research use only.
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Heparin sodium is a sodium salt of heparin which is a naturally-occurring anticoagulant used for anticoagulation for cardiovascular disease. It is an inhibitor of activated coagulation factors such as Factors Xa and IIa (thrombin).
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B0084-325124 10 g $188 In stock
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Brife Description:
anticoagulant for cardiovascular disease
Innohep; Reviparin sodium; Tinzaparin sodium; Heparin, sodium salt; Logiparin; Panheprin
anticoagulation for cardiovascular disease
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1.Warfarin continuation vs interruption during procedures of cardiac rhythm devices: A Meta-analysis of randomized controlled trials.
Sun H1, Du B1, Liu X2, Yang S1, Yang P2. J Pak Med Assoc. 2016 Apr;66(4):458-65.
To compare the safetyand efficacy of warfarin treatment continuation and heparin-bridging therapy during cardiac rhythm device (CRD) implantation in patients chronically treated with anticoagulants.We performed a search and analysis of peer-reviewed studies Four randomized controlled trials (RCTs)were included in our analysis with 941 patients. The bleeding risk in patients continuing warfarin perioperatively was lower than those interrupting warfarin and using a heparin-bridge (RD -0.08, 95% CI -0.17 to 0.02, p< 0.05). There was no significant difference in ischaemic risk between two methods (RD 0, 95% CI -0.01 to 0.02, p=1.00). Hence, in patients undergoing long-term warfarin therapy, continuation of warfarin treatment is a safe and efficacious perioperative strategy for during CRD implantations, while interruption of warfarin with a heparin bridge may increase the bleeding risk in these patients.
2.Heparin as a bundler in a self-assembled fibrous network of functionalized protein-based polymers.
Włodarczyk-Biegun MK, Slingerland CJ, Werten MW, van Hees I, de Wolf FA, de Vries R, Cohen Stuart MA, Kamperman M. Biomacromolecules. 2016 Apr 29. [Epub ahead of print]
Nature shows excellent control over the mechanics of fibrous hydrogels by assembling protein fibers into bundles of well-defined dimensions. Yet, obtaining artificial materials displaying controlled bundling remains a challenge. Here, we developed genetically engineered protein-based polymers functionalized with heparin-binding KRSR domains and show controlled bundling using heparin as a binder. The protein polymer forms fibers upon increasing the pH to physiological values and at higher concentrations fibrous gels. We show that addition of heparin to the protein polymer with incorporated KRSR domains, induces bundling, which results in faster gel formation and stiffer gels. The interactions are expected to be primarily electrostatic and fiber bundling has an optimum when the positive charges of KRSR are approximately in balance with the negative charges of the heparin. Our study suggests that, generally, a straightforward method to control the properties of fibrous gels is to prepare a fiber former with specific binding domains and then simply adding an appropriate amount of binder.
3.Negative Heparin-Induced Thrombocytopenia Test Result After Massive Transfusion: Believe It or Not?
Senzel L1, Coldren D2. Am J Clin Pathol. 2016 Mar 24. pii: aqw031. [Epub ahead of print]
OBJECTIVES: Diagnosis of heparin-induced thrombocytopenia (HIT) is complicated by a high false-positive rate for the screening enzyme immunoassay (EIA) and limited availability of confirmatory platelet activation assays such as serotonin release assay (SRA). We evaluate the impact of a massive transfusion on EIA and SRA testing and emphasize that the timing of the confirmatory sample is important.
4.A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding.
Kremers RM1, Bosch YP, Bloemen S, de Laat B, Weerwind PW, Mochtar B, Maessen JG, Wagenvoord RJ, Al Dieri R, Hemker HC. Thromb Haemost. 2016 Apr 28;116(2). [Epub ahead of print]
Cardiac surgery with cardiopulmonary bypass (CPB) is associated with blood loss and post-surgery thrombotic complications. The process of thrombin generation is disturbed during surgery with CPB because of haemodilution, coagulation factor consumption and heparin administration. We aimed to investigate the changes in thrombin generation during cardiac surgery and its underlying pro- and anticoagulant processes, and to explore the clinical consequences of these changes using in silico experimentation. Plasma was obtained from 29 patients undergoing surgery with CPB before heparinisation, after heparinisation, after haemodilution, and after protamine administration. Thrombin generation was measured and prothrombin conversion and thrombin inactivation were quantified. In silico experimentation was used to investigate the reaction of patients to the administration of procoagulant factors and/or anticoagulant factors. Surgery with CPB causes significant coagulation factor consumption and a reduction of thrombin generation.
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CAS 9041-08-1 Heparin sodium

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