|Description||Helioxanthin 8-1 is an analogue of helioxanthin, which exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity. It showed the most potent antiHBV activity among those helioxanthin analogues tested. It exhibited moderately potent activity against HIV and effective inhibition on DHBV replication. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam.|
|Synonyms||Helioxanthin analogue 8-1|
Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
Telbivudine is an antiviral drug used in the treatment of hepatitis B infection. It is marketed by Swiss pharmaceutical company Novartis under the trade names S...
Clevudine is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphos...
Merimepodib is orally bioavailable IMPDH inhibitor.
Lagociclovir is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV.
An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.
AB-423 is a small-molecule inhibitor of HBV core protein used to treat chronic HBV infection. In preclinical study, AB-423 was indicated to damage assembly of t...
Bay 41-4109 less active enantiomer
Bay 41-4109 less active enantiomer exhibits less activity than Bay 41-4109 that is a novel class of drugs and inhibits hepatitis B virus (HBV) capsid formation ...
Helioxanthin derivative 5-4-2
Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HB...
Entecavir-triphosphate is a highly potent inhibitor of wild-type HBV Pol and is 100- to 300-fold more potent than lamivudine-triphosphate against 3TC-resistant ...
Helioxanthin and its analogues decreased cellular RNA levels of HBV and antigen expression as well as selective inhibition of HBV replication in a cell culture ...
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C.
Helioxanthin 8-1 is an analogue of helioxanthin, which exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity. It showed the most potent antiHBV activi...
ABI-H-0731 is one of a class of novel and oral CpAMs developed for the potential use to treat chronic hepatitis B virus infection and disorders associated with ...