|Description||HCV371 is a potent and selective HCV NS5B polymerase inhibitor. It binds the NS5B with an apparent dissociation constant of 150 nM, which leads to high selectivity and lack of cytotoxicity in the antiviral assays. It displayed broad inhibitory activities against the NS5B RdRp enzyme. It showed no inhibitory activity against a panel of human polymerases, including mitochondrial DNA polymerase gamma and other unrelated viral polymerases.|
|Synonyms||HCV-371; HCV 371; HCV371. (R)-2-(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid|
|Solubility||Soluble in DMSO, not in water|
|Quality Standard||In-house standard|
|Boiling Point||575.2±45.0 °C | Condition: Press: 760 Torr|
|Density||1.29±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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HCV371 is a potent and selective HCV NS5B polymerase inhibitor. It binds the NS5B with an apparent dissociation constant of 150 nM, which leads to high selectiv...
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