|Targets||5-HT Receptor | Microtubule/Tubulin | Tau|
|Description||Harmine induces apoptosis and inhibits proliferation, migration and invasion of human gastric cancer cells, which may be mediated by down-regulation of COX-2 expression.|
|Appearance||Off-White to Brown-Orange Solid|
|Solubility||Soluble in DMSO|
|Storage||Store at 2-8 °C|
|Application||Potent and selective inhibitor of DYRK1A|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
|Melting Point||>164 ºC|
Rizatriptan Benzoate is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.
Combretastatin A4, under the IUPAC name 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, inhibits tubulin polymerization (IC50= 2.2 μM). It has demons...
Dolastatin 10 trifluoroacetate inhibits tubulin polymerization and induces tubulin aggregation in vitro.
Lexibulin dihydrochloride is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. It inh...
m-Chlorophenylbiguanide hydrochloride is the hydrochloride salt of chlorophenylbiguanide, which is a selective and prototypical potent 5-HT3 serotonin receptor ...
Methylene Blue, whose brand name is Calbiochem, inhibits tau filament formation (IC50 = 1.9 μM) and soluble guanylyl cyclase.
SB 228357 is a 5-HT2C/2B receptor antagonist (pKi = 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors, respectively) used in the treatment of irritable bowel synd...
lexibulin, also known as CYT997, is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activ...
LP 20 hydrochloride
LP 20 hydrochloride is a ligand of the 5-HT7 receptor. It shows agonist and antagonist activity.
NBOH-2C-CN hydrochloride is a selective 5-HT2A agonist.
C2N 8E12 is a humanized antibody that currently in clinical development works to protect against Alzheimer’s disease by stimulating the immune system to activat...
Vinorelbine, also called Navelbine, a 5′NOR semisynthetic vinca alkaloid which arrests tumor cell growth in metaphase by binding to tubulin and preventing form...
ML 10302 hydrochloride
ML 10302 hydrochloride is a 5-HT4 agonist with EC50 value of 4 nM. It can increase sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhi...
(R)-(-)-LY 426965 dihydrochloride
(R)-(-)-LY 426965 dihydrochloride is a selective 5-HT1A antagonist that is less active than its opposite (S)-(+)-enantiomer LY 426965.
The salt form of (R)-6-hydroxybuspirone, which is an active metabolite of Buspirone. It is a 5-HT1A partial agonist with higher affinity for 5HT1A receptor comp...
Pimavanserin is a potent and selective 5-HT2A receptor inverse agonist used in the treatment of Parkinson’s disease psychosis.
5-HT3 antagonist 1
A potent and selective antagonist of serotonin 3 (5-HT3) receptor
Vinflunine induces apoptosis in neuroblastoma SK-N-SH cells through a postmitotic G1 arrest and a mitochondrial pathway in a concentration-dependent manner with...
INDY，under the IUPAC name 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one, is a DYRK1A/B inhibitor (DYRK1B: IC50= 0.23μM; DYRKA: IC50= 0.230.24μM)....
Epothilone B, also called Patupilone, is a microtubule stabilization agent (EC0.01= 1.8 μM). It induces mitotic arrest at the G2-M transition in Hs578T (IC50 = ...