Haloprogin - CAS 777-11-7
Catalog number:
777-11-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H4Cl3IO
Molecular Weight:
361.39
COA:
Inquire
Targets:
Antifungal
Description:
Haloprogin is an antifungal drug. It can be used for the treatment of athlete's foot and other fungal infections.
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Purity:
98%
Appearance:
Powder
Synonyms:
M 1028; NSC 100071; 1,2,4-Trichloro-5-[(3-iodo-2-propynyl)oxy]benzene; 2,4,5-Trichlorophenyl γ-Iodopropargyl Ether; 3-Iodo-2-propynyl 2,4,5-Trichlorophenyl Ether; 1,2,4-Trichloro-5-[(3-iodo-2-propyn-1-yl)oxy]benzene
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
athlete's foot and other fungal infections.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
CTETYYAZBPJBHE-UHFFFAOYSA-N
InChI:
1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2
Canonical SMILES:
c1(c(cc(Cl)c(c1)Cl)Cl)OCC#CI
1.In vitro activity of ME1401, a new antifungal agent.
Yamaguchi H, Uchida K, Hiratani T, Hara T, Fukuyasu H, Kazuno Y, Inouye S. Antimicrob Agents Chemother. 1986 Nov;30(5):705-12.
The in vitro antifungal activity of ME1401, a potential topical antifungal agent, was compared with that of haloprogin, clotrimazole, miconazole, tolnaftate, and ciclopirox olamine by using an agar dilution procedure. ME1401 showed a broad antifungal spectrum and inhibited all of the 428 strains of 52 species of pathogenic yeasts and filamentous fungi tested at concentrations ranging from 0.01 to 12.5 micrograms/ml. In general, the activity of ME1401 was comparable or superior to that of clotrimazole and was greater than that of haloprogin and the other reference drugs under the conditions used. Only tolnaftate was superior to ME1401 in its activity against clinical isolates of Trichophyton rubrum. ME1401 showed no cross-resistance with any of the reference drugs and exhibited potent fungicidal activity.
2.Current treatment of dermatophytoses.
Hay RJ. Acta Derm Venereol Suppl (Stockh). 1986;121:117-23.
There is a wide variety of highly effective topical antifungal agents available for the treatment of dermatophytosis. In more widespread infections or those involving hair or nails oral therapy with griseofulvin or ketoconazole can be used. With both forms of therapy certain types of dermatophyte infection are clinically resistant to treatment. These include onychomycosis, infections of the sole caused by T.rubrum and certain forms of tinea capitis (e.g. favus) or tinea corporis. In future consideration needs to be given to find the optimum duration and frequency of treatment and better methods of allowing penetration of drugs into nails and heavely keratinised sites.
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CAS 777-11-7 Haloprogin

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