Halcinonide - CAS 3093-35-4
Catalog number: 3093-35-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H32ClFO5
Molecular Weight:
454.96
COA:
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Targets:
Others
Description:
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
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Purity:
>98%
Synonyms:
Halcinonide
MSDS:
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1.[Multicenter randomized clinical study of high-intensity focused ultrasound and cortical hormone in the treatment of non-neoplastic epithelial disorders of vulva].
Shi HH1, Zhu L2, Yang Y, Jin HM, Li RZ, Liang ZQ, Lang JH. Zhonghua Yi Xue Za Zhi. 2013 Nov 5;93(41):3291-3.
OBJECTIVE: To evaluate the efficacy of high-intensity focused ultrasound (HIFU) and cortical hormone in the treatment of non-neoplastic epithelial disorders of vulva.
2.[Determination of evodiamine and rutaecarpine of compound Wuzhuyu cataplasm in plasma by SPE-HPLC: application to its pharmacokinetics].
Yin W1, Li M, Liu S, Kang C, Wang Y, Zhou Z, Tong H. Zhongguo Zhong Yao Za Zhi. 2009 Nov;34(22):2946-9.
OBJECTIVE: To establish a SPE-HPLC method for the determination and pharmacokinetic study of evodiamine and rutacarpine in rat plasma.
3.Influence of the timing of ultrasound application on the penetration of corticosteroids.
Clijsen R1, Baeyens JP, Barel AO, Clarys P. Skin Res Technol. 2013 Feb;19(1):e279-82. doi: 10.1111/j.1600-0846.2012.00639.x. Epub 2012 Jun 20.
BACKGROUND: The application of ultrasound to enhance the transdermal transport of drugs is often referred to as 'sonophoresis'. In physiotherapy sonophoresis is applied to the skin through two different procedures: (1) the pre-treatment procedure where the skin is treated with ultrasound irradiation prior to the drug application and (2) a simultaneous treatment mode, where the skin is treated with ultrasound during the application of the pharmacologic substance. The aim of this study was to compare the bioavailability of halcinonide in the stratum corneum comparing the ultrasound pre-treatment vs. the simultaneous treatment method.
4.Demonstration of the biphasic release of 0.1% halcinonide cream.
Draelos ZD. J Drugs Dermatol. 2015 Jan;14(1):89-90.
Halcinonide in Halog Cream is formulated in a unique cream base that allows a biphasic release of this Class II steroid. Halcinonide in this product exists in two phases--a solution phase that is released immediately and a suspension phase that has a delayed release over time. The goal of this study was to evaluate this biphasic release of halcinonide into the skin using a novel noninvasive method. A dermal tape stripping protocol was used to quantify halcinonide concentration at 6 sequential depths in the skin of 4 sites on the forearms of 5 subjects. D-Squame strips were sequentially applied with consistent pressure and removed at 1, 3, 6, and 9 hours after application of halcinonide. Halcinonide was extracted from the strips and quantified using liquid chromatography mass spectrometry. The highest concentration of halcinonide was detected in strip 1 from the superficial stratum corneum with subsequent reduction in deeper stratum corneum layers as expected.
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CAS 3093-35-4 Halcinonide

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