BDA-366 is a small-molecule antagonist of Bcl2-BH4 domain with high affinity and selectivity for Bcl2-BH4. BDA-366 induces apoptosis in multiple myeloma cells v...
A-1331852, a substituted benzothiazole, is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL (Ki≤ 10 pM). A-1331852 is an orally apoptosis-inducing agent...
A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family member...
Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, ...
MIM1 is a small molecule inhibitor of Mcl-1 (IC50= 4.8 uM) by selectively targets the BH3-binding pocket.
BH3I-1 is a cell-permeable inhibitor that targets Bcl-2 family protein. It inhibits the binding of BH3 peptides to Bcl-xL and induces apoptosis of Bcl-xL expres...
Navitoclax is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antine...
Bax channel blocker
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).
Gossypol Acetic Acid
The Acetate acid salt form of gossypol which may represent a promising new anticancer agent with a novel molecular mechanism and warrants further investigation ...
A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft t...
Marinopyrrole A, a new Mcl-1 inhibitor, could influence Mcl-1-Bim interaction and induce the degradation of Mcl-1 proteasomal and also lead to the apoptosis of ...
SMBA 1 is a selelctive and high affinity Bax activator (Ki = 43.3 nM) that binds to the S184 binding pocket and inhibits Bax phosphorylation. SMBA 1 exhibits no...
Gossypol is an orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cel...
Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.
Pyridoclax, a pyridine derivative, has been found to be a Mcl-1 inhibitor that could induce apoptosis of cancer cells. IC50: 25 nM(Kd).
Mcl1-IN-1 is a potent Mcl-1-selective inhibitor with IC50 of 2.4 uM, relative to the related Bcl-2 family protein Bcl-xL.
WEHI-539, a selective BCL-XL inhibitor that can be function as a single-agent inducer of apoptosis while sparing normal cells, it leads to MOMP and apoptosis du...
ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 inhibits proliferation of Her2-po...
Gambogic acid is a natural product inhibitor of Hsp90.